대장암 환자에서 MMP-2 (Matrix Metalloproteinase Type 2)와 TIMP-2 (Tissue Inhibitor of Metalloproteinase Type 2)의 발현
Expression of MMP-2 (Matrix Metalloproteinase Type 2) and TIMP-2 (Tissue Inhibitor of Metalloproteinase Type 2) in Colorectal Cancer
백무준, 주종우, 채만규, 김성용, 이문수, 김창호, 김대중, 황규윤, 송옥평,
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백무준 ( Baek Moo-Jun )
순천향대학교 의과대학 외과학교실
주종우 ( Chu Chong-Woo )
순천향대학교 의과대학 외과학교실
채만규 ( Chae Man-Kyu )
순천향대학교 의과대학 외과학교실
김성용 ( Kim Sung-Yong )
순천향대학교 의과대학 외과학교실
이문수 ( Lee Moon-Soo )
순천향대학교 의과대학 외과학교실
김창호 ( Kim Chang-Ho )
순천향대학교 의과대학 외과학교실
김대중 ( Kim Dae-Joong )
순천향대학교 의과대학 병리학교실
황규윤 ( Hwang Kyu-Yoon )
순천향대학교 의과대학 예방의학교실
송옥평 ( Song Ok-Pyung )
순천향대학교 의과대학 외과학교실
KMID : 0356720000160050285
Abstract
Purpose: The matrix metalloproteinases (MMPs) have been implicated in proteolysis of basement membrane for initiation of metastatic cascade. Tissue inhibitors of metalloproteinases (TIMPs) are specific inhibitors of MMPs. The purpose of this study was to evaluate the expression of MMP-2 and TIMP-2 in human colorectal carcinomas.
Methods: The paraffin blocks of 140 colorectal carcinomas were recalled and immunostained with monoclonal antibodies specific for MMP-2 and TIMP-2. These antibodies were effective on formalin fixed, paraffin embedded sections. The rate of stain was estimated, and therelationships between the expression and the stage, the differentiation, lymph node metastasis, distant metastasis and the survival rate were assessed.
Results: MMP-2 was present in 31.4% of colorectal cancers. TIMP-2 was identified in 63.6% of tumors. The expression of MMP-2 was significantly associated with the presence of lymph-node metastasis, the stage, and the presence of distant metastasis. However the expression of TIMP-2 was not correlated with any risk factors.
Conclusion: These results suggest that MMP-2 could predict the ability of cancer invasion and be used as a prognostic factor for the colorectal adenocarcinoma.
키워드
Colorectal cancer;MMP 2;TIMP 2
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