대장암 조직과 정상 대장 조직의 Gastrin 및 Gastrin/CCK-B 수용체 mRNA의 발현
The Expression of Gastrin and Gastrin/ CCK-B Receptor mRNA in Cancer and Normal Tissue of Large Intestine
오재환, 황유진, 정문기, 강동훈,
소속 상세정보
오재환 ( Oh Jae-Hwan )
가천의과학대학교 외과학교실
황유진 ( Hwang Yu-Jin )
가천의과학대학교 의학전문대학원 분자생물학교실
정문기 ( Chung Moon-Ki )
가천의과학대학교 내과학교실
강동훈 ( Kang Dong-Hoon )
가천의과학대학교 내과학교실
KMID : 0356720010170010001
Abstract
Purpose: Gastrin, a peptide hormone produced by the G cells of the gastric antrum, plays a major role in regulating acid secretion in the stomach, and acts as a trophic factor in the gastrointestinal tract. The relationship between gastrin and the development of colorectal cancer remains controversial. To study its possible role in development or proliferation of colorectal cancer, we evaluated the expression of gastrin and gastrin/CCK-B receptor mRNA in cancer and normal tissue from colorectal cancer patients. We also reviewed clinical records to evaluate the correlations between gastrin receptor expression and clinical characteristics of colorectal cancer.
Methods: Reverse transcription-polymerase chain reaction (RT-PCR) was used to evaluate mRNA expression for gastrin and gastrin/CCK-B receptor in 26 surgical specimens of colorectal cancer.
Results: The mRNA expression of gastrin was detected in 24 out of 26 cancer specimens and 9 out of 26 normal colon specimens (p＜0.05). The mRNA expression of gastrin/ CCK-B receptor was detected in 18 out of 26 cancer specimens and 17 out of 26 normal colon specimens (p＞0.05). There was no significant correlation between gastrin receptor expression and clinical characteristics of colorectal cancer.
Conclusion: The gastrin gene products might be more important than gastrin/CCK-B receptor in development
or proliferation of colorectal cancer, which supports the hypothesis that gastrin gene products play a role in proliferation of colorectal cancer as an autocrine factor.
키워드
가스트린;가스트린수용체;대장암
Gastrin;Gastrin/CCK-B receptor;Colorectal cancer
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