결장 및 직장암에서 면역화학염색법을 이용한 Thymidylate Synthase 발현
Thymidylate Synthase Expression Using Immunohistochemical Staining in Colorectal Cancer
안창혁, 서학준, 김기환, 오승택, 김정수, 전해명, 임근우, 이은정,
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안창혁 ( An Chang-Hyeok )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
서학준 ( Seo Hak-Jun )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
김기환 ( Kim Kee-Hwan )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
오승택 ( Oh Seung-Taek )
가톨릭대학교 의과대학 강남성모병원 외과
김정수 ( Kim Jeong-Soo )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
전해명 ( Jeon Hae-Myung )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
임근우 ( Lim Keun-Woo )
가톨릭대학교 의과대학 의정부성모병원 외과학교실
이은정 ( Lee Eun-Jung )
가톨릭대학교 의과대학 의정부성모병원 임상병리학교실
KMID : 0356720010170060316
Abstract
Purpose: Thymidylate synthase (TS) is a critical enzyme in the DNA synthesis and an important target of cancer chemotherapeutic agents, such as 5-fluorouracil (5-FU). Recent studies suggest that TS expression is related to the prognosis of various cancers and the mechanism of chmotherapeutic drug resistance. This retrospective study was performed to determine whether TS expressions in primary colorectal tumors influence the overall survival and recurrence for patients with colorectal cancer.
Methods: Intratumoral TS expression was evaluated by immunohistochemical staining using TS-106 monoclonal antibody in primary colorectal cancers of 64 patients who had undergone surgery from July, 1995 to June, 1999. The
relationship between TS expressions and patients’ survival was evaluated statistically. The median follow-up period was 25.7 months.
Results: Overall positive TS expression rate was relatively high (54.7%) in colorectal cancers, and overall
disease-free survival rate was significantly higher in the TS positive group (P=0.0204). But there was no statistically significant differences in overall survival rates (P=0.249) and tumor recurrence rates (P=0.732) between positive TS group and negative TS group.
Conclusions: These results suggest that TS expression status in the colorectal cancer tissue is only related to the overall disease-free survival rates, not the overall survival rates and tumor recurrence rates. More objective method and long term follow up study will be required for accurate assessment of clinical importance of TS expression in colorectal cancers.
키워드
결장직장암;생존과 재발
Thymidylate synthase;Colorectal cancer;Survival and recurrence
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