´ëÀå¾Ï¿¡¼ ¥â-catenin ¹× p53 ´Ü¹éÀÇ ¹ßÇö¾ç»ó°ú Á¾¾çÀÇ º´¸®ÇÐÀû Ư¼º °£ÀÇ »óÈ£°ü°è
Correlation of ¥â-catenin and p53 Protein Expression with Clinico-pathologic Characteristics of Colorectal Cancer
¹®±æ¹Î, ¹Ú¿ëÁø, ±èÇѼº, ¹Ú¼ºÇý, ±èÁöÀÏ, ±è±âÈ«, ¼Ûº´ÁÖ, À̸í¼ö, ±èö³², À弮ȿ,
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¹®±æ¹Î ( Moon Kil-Min )
ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ ÀÏ»ê¹éº´¿ø ¿Ü°úÇб³½Ç
¹Ú¿ëÁø ( Park Young-Jin )
ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ ÀÏ»ê¹éº´¿ø ¿Ü°úÇб³½Ç
±èÇѼº ( Kim Han-Seong )
ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ Çغκ´¸®Çб³½Ç
¹Ú¼ºÇý ( Park Seong-Hye )
ÀÎÁ¦´ëÇб³ ÀÏ»ê¹éº´¿ø Çغκ´¸®°ú
±èÁöÀÏ ( Kim Ji-Il )
ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ ÀÏ»ê¹éº´¿ø ¿Ü°úÇб³½Ç
±è±âÈ« ( Kim Ki-Hong )
ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ ÀÏ»ê¹éº´¿ø ¿Ü°úÇб³½Ç
¼Ûº´ÁÖ ( Song Byung-Joo )
ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ ÀÏ»ê¹éº´¿ø ¿Ü°úÇб³½Ç
À̸í¼ö ( Lee Myung-Soo )
ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ ÀÏ»ê¹éº´¿ø ¿Ü°úÇб³½Ç
±èö³² ( Kim Chul-Nam )
ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ ÀÏ»ê¹éº´¿ø ¿Ü°úÇб³½Ç
À弮ȿ ( Chang Surk-Hyo )
ÀÎÁ¦´ëÇб³ ÀÇ°ú´ëÇÐ ÀÏ»ê¹éº´¿ø ¿Ü°úÇб³½Ç
KMID : 0356720020180050311
Abstract
Purpose: Both the ¥â-catenin and p53 play a crucial role in the process of colon carcinogenesis. The expression of ¥â-catenin and/or p53 has been reported to be associated with pathologic features of tumor and prognosis of patients. In
addition, several recent studies have suggested a close biological association between p53 expression and nuclear ¥â-catenin level. We analyzed the pathologic variables and p53 expression according to the intra-nuclear ¥â-catenin expression in colon cancer to make such assumptions more clear since they are still controversial issues.
Methods: The expressions of ¥â-catenin, p53 and Ki-67 protein in colon cancer were determined by immunohistochemical staining. The relationship between these protein expressions and tumor characteristics was statistically analyzed.
Results: The intra-nuclear ¥â-catenin accumulation was not associated with any of the pathological variables including lymph node metastasis and tumor differentiation, but it was correlated with higher level of Ki-67 proliferation index
(P=0.006) and negative staining of p53 (P =0.015). Positive p53 staining was significantly associated with lymph node metastasis (P=0.006), lymphatic invasion (P=0.03) and venous invasion (P=0.02).
Conclusion: These results support the suggestion that intra-nuclear accumulation of ¥â-catenin may regulate the p53 activity in colorectal cancer. In addition, positive staining of p53 may be used as a valuable prognostic indicator since
it was strongly associated with lymph node metastasis, lymphatic and venous invasion.
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Colorectal cancer;¥â-catenin;p53;Lymph node metastasis;Differentiation
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