결장직장암에서의 Cyclooxygenase-2와 Inducible Nitric Oxide Synthase의 발현
Expression of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Colorectal Cancer
양근호, 배병노, 김정연, 김기환, 한세환, 김홍주, 김영덕, 김홍용, 김성준,
소속 상세정보
양근호 ( Yang Keun-Ho )
인제대학교 의과대학 상계백병원 외과학교실
배병노 ( Bae Byung-Noe )
인제대학교 의과대학 상계백병원 외과학교실
김정연 ( Kim Jung-Yeon )
인제대학교 상계백병원 병리과
김기환 ( Kim Ki-Whan )
인제대학교 의과대학 상계백병원 외과학교실
한세환 ( Han Se-Hwan )
인제대학교 의과대학 상계백병원 외과학교실
김홍주 ( Kim Hong-Joo )
인제대학교 의과대학 상계백병원 외과학교실
김영덕 ( Kim Young-Duck )
인제대학교 의과대학 상계백병원 외과학교실
김홍용 ( Kim Hong-Yong )
인제대학교 의과대학 상계백병원 외과학교실
김성준 ( Kim Seong-Joon )
인제대학교 의과대학 상계백병원 예방의학교실
KMID : 0356720030190030144
Abstract
Purpose: Recently, it has been recognized that both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) produce important endogeneous factors of human tumor progression. The aims of this study is to investigate the correlation between the expression of COX-2 and iNOS and to assess the clinicopathological significance of COX-2 and iNOS expression in patients with colorectal cancer.
Methods: One hundred and five patients, who underwent curative resection of colorectal cancer from 1994 to 1997 were analyzed retrospectively. The monoclonal antibody to the COX-2 and iNOS were used for the immunohistochemical analysis.
Results: In 105 patients the COX-2 and iNOS positive rate were 86.7% and 69.5% respectively. There was significant correlation between COX-2 and iNOS expression (r=0.378, P?¼0.01), that is, the lesions which expressed high level of COX-2 also expressed iNOS highly. The proliferation index (Ki-67 labeling index) was correlated with iNOS (P=0.013), and the microscopic differentiation with COX-2 (P=0.004). However, the expression of COX-2 and iNOS proteins did not correlate with any other clinicopathological parameters including patient survival.
Conclusion: Although the pattern of positive expression was similar in both enzymes, the expression of both enzymes was not related to prognosis in patients with colorectal cancer. But COX-2 and iNOS seems to have a role not only in carcinogenesis but also tumor cells proliferation. To evaluate the exact role of these enzymes, further studies of the apoptosis and cancer metastasis and of links between the cancer related factors of COX-2 and iNOS are warranted.
키워드
결장직장암
Cyclooxygenase-2;Inducible nitirc oxide synthase;Colorectal cancer;Cyclooxygenase-2;Inducible nitirc oxide synthase
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