소장 및 대장에서 발생한 위장관 간질 종양에서 c-kit 유전자 변이 및 예후 인자 분석
Analysis of c-kit Gene Mutation and Prognostic Factors of GISTs in the Small and the Large Bowel
박종경, 윤상섭, 강원경, 조현민, 김지연, 최승혜, 오승택, 오세정, 이성, 전해명,
소속 상세정보
박종경 ( Park Jong-Kyung )
가톨릭대학교 의과대학 외과학교실
윤상섭 ( Yun Sang-Seob )
가톨릭대학교 의과대학 외과학교실
강원경 ( Kang Won-Kyung )
가톨릭대학교 의과대학 외과학교실
조현민 ( Cho Hyun-Min )
가톨릭대학교 의과대학 외과학교실
김지연 ( Kim Ji-Youn )
가톨릭대학교 의과대학 외과학교실
최승혜 ( Choi Seung-Hye )
가톨릭대학교 의과대학 외과학교실
오승택 ( Oh Seung-Tack )
가톨릭대학교 의과대학 외과학교실
오세정 ( Oh Se-Jeong )
가톨릭대학교 의과대학 외과학교실
이성 ( Lee Sung )
가톨릭대학교 의과대학 외과학교실
전해명 ( Jeon Hae-Myung )
가톨릭대학교 의과대학 외과학교실
KMID : 0356720040200010001
Abstract
Purpose: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors which arise anywhere in the tubular GI tract. The prognosis for GISTs that develop in the small and the large bowel is worse than it is for those that develop at other sites. We examined the significance of c-kit mutation as an independent prognostic factor for GISTs.
Methods: The hospital records of 27 patients with GISTs in the small and the large bowel who were seen from January 1991 to December 2001 at the Department of Surgery, The Catholic University School of Medicine, were reviewed. c-kit mutation was measured by using the PCR and DNA sequencing.
Results: Mutations in exon 11 were found in 5 cases (83.3%), exon 9 in 1 case (16.7%), and no mutations were noted in exon 13 and exon 17. All mutations in exon 11 were found in codon 560-570. c-kit mutation was observed more frequently in high-risk patients, and there was a significant difference between c-kit mutation and the survival rate (P=0.048).
Conclusions: We think that codon 550～560 in exon 11 of the c-kit gene is a hotspot of mutation, but c-kit mutation is uncertain as an independent prognostic factor for GISTs. J Korean Soc Coloproctol 2004;20:1-7
키워드
위장관 간질 종양;c-kit 유전자 변이;예후 인자
Gastrointestinal stromal tumors;c-kit mutation;Prognostic factor
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