대장암에서 Survivin의 발현과 예후와의 관계
Expression of Survivin and Its Correlation with Prognosis in Colorectal Cancer
백무준, 김창진, 박내경, 신응진, 장용석, 김재준, 김성용, 이문수, 김창호, 송옥평,
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백무준 ( Baek Moo-Jun )
순천향대학교 의과대학 외과학교실
김창진 ( Kim Chang-Jin )
순천향대학교 의과대학 병리학교실
박내경 ( Park Nae-Kyung )
순천향대학교 의과대학 외과학교실
신응진 ( Shin Eung-Jin )
순천향대학교 의과대학 외과학교실
장용석 ( Jang Yong-Seog )
순천향대학교 의과대학 외과학교실
김재준 ( Kim Jae-Joon )
순천향대학교 의과대학 외과학교실
김성용 ( Kim Sung-Yong )
순천향대학교 의과대학 외과학교실
이문수 ( Lee Moon-Soo )
순천향대학교 의과대학 외과학교실
김창호 ( Kim Chang-Ho )
순천향대학교 의과대학 외과학교실
송옥평 ( Song Ok-Pyung )
순천향대학교 의과대학 외과학교실
KMID : 0356720060220020125
Abstract
Purpose: Survivin is involved in both the control of cell division and the inhibition of apoptosis. Specifically, its anti-apoptotic function is related to the ability to inhibit caspases directly or indirectly. This study examined the expression patterns of survivin in normal colorectal tissues and in colorectal cancer tissues to determine whether the expression of survivin is associated with either the colorectal cancer characteristics or the prognosis.
Methods: 4μm sections of the formalin-fixed paraffin-embedded samples of colorectal cancer tissues were the immunostained using antibodies for survivin. The immunostain was recorded as 0∼3 depending on the stain intensity distribution in the cytoplasm and the nucleus.
Results: Survivin was localized in the nucleus and/or cytoplasm of tumor cells. We could differentiate between cytoplasmic and nuclear localization of survivin protein expression. Among the cancer expressions, 35.8% demonstrated nuclear staining, and 51.9% demonstrated cytoplasm staining. Statistical analysis revealed that cytoplasmic survivin expression was correlated with lymph-node metastasis, tumor stage, and patient survival.
Conclusions: Survivin expression was correlated with clinicopathologic prognostic parameters and with the outcome. Thus, it can be both a useful diagnostic marker for colorectal carcinomas and an important source of prognostic information for patients with a colorectal carcinoma. Survivin will become a potential new target in anti-cancer therapy in near future. J Korean Soc Coloproctol 2006; 22:125-131
키워드
대장암;Survivin;면역조직염색법;예후
Colorectal cancer;Immunohistochemical stain;Prognosis
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