림프절 전이가 없는 결직장암에서 p27kip1의 예후인자로서의 역할
Prognostic Significance of p27kip1 Expression in Node Negative Colorectal Carcinoma
송상현, 배병노, 이우용, 양근호, 김기환, 한세환, 김홍주, 김영덕, 김홍용, 김정연,
소속 상세정보
송상현 ( Song Sang-Hyun )
인제대학교 의과대학 상계백병원 외과학교실
배병노 ( Bae Byung-Noe )
인제대학교 의과대학 상계백병원 외과학교실
이우용 ( Lee Woo-Yong )
인제대학교 의과대학 상계백병원 외과학교실
양근호 ( Yang Keun-Ho )
인제대학교 의과대학 상계백병원 외과학교실
김기환 ( Kim Ki-Hwan )
인제대학교 의과대학 상계백병원 외과학교실
한세환 ( Han Se-Hwan )
인제대학교 의과대학 상계백병원 외과학교실
김홍주 ( Kim Hong-Ju )
인제대학교 의과대학 상계백병원 외과학교실
김영덕 ( Kim Young-Duk )
인제대학교 의과대학 상계백병원 외과학교실
김홍용 ( Kim Hong-Yong )
인제대학교 의과대학 상계백병원 외과학교실
김정연 ( Kim Jung-Yeon )
인제대학교 의과대학 상계백병원 병리학교실
KMID : 0356720070230010034
Abstract
Purpose: Dukes’ A & B colorectal cancer patients are often excluded from adjuvant chemotherapy following potentially curative surgery because they are expected to have good long-term survival. However, actually 20∼30% of these patients suffer from recurrent disease, so it would be helpful for these patients of recurrent disease to be able to select a high risk group.
Methods: In 78 Dukes’ A & B colorectal cancers, we investigated by immunohistochemistry the role of molecular markers, such as p27kip1, p53, Ki-67, and Skp2, in identifying high-risk patients.
Results: Patients with low p27kip1 expression showed poor overall survival compared to those with high p27kip1 expressions (55.3 versus 66.7 months, P=0.018). The only significant factor associated with p27kip1 expression was p53 expression. The low p27kip1 expression and positive p53 expression group had poor overall survival (54.3 months, P=0.036).
Conclusion: In a node-negative colorectal carcinoma, the molecular marker p27kip1 does not play an independent prognostic role, but it may have prognostic significance in correlation with other markers such as p53, Ki-67, and Skp2. The assessment of molecular alterations may be useful to node-negative colorectal patients in identifying the high risk group that may benefit from adjuvant chemotherapy. J Korean Soc Coloproctol 2007;23:34-40
키워드
결직장암;p27kip1;Skp2;예후
Colorectal cancer;p27kip1;Skp2;Prognosis
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