T2 대장암에서 E-cadherin과 beta-catenin 복합체 발현의 임상적 의의
Clinical Significance of E-cadherin and beta-catenin Complex Expression in T2 Colorectal Cancer
김진수, 고용택, 허혁, 민병소, 김남규, 손승국, 조장환, 안중배, 김호근,
소속 상세정보
김진수 ( Kim Jin-Soo )
연세대학교 의과대학 외과학교실
고용택 ( Ko Yong-Taek )
연세대학교 의과대학 외과학교실
허혁 ( Hur Hyuk )
연세대학교 의과대학 외과학교실
민병소 ( Min Byung-Soh )
연세대학교 의과대학 외과학교실
김남규 ( Kim Nam-Kyu )
연세대학교 의과대학 외과학교실
손승국 ( Sohn Seung-Kook )
연세대학교 의과대학 외과학교실
조장환 ( Cho Jang-Hwan )
연세대학교 의과대학 외과학교실
안중배 ( Ahn Joong-Bae )
연세대학교 의과대학 내과학교실
김호근 ( Kim Ho-Guen )
연세대학교 의과대학 병리학교실
KMID : 0356720080240020091
Abstract
Purpose: Expression of adhesion molecules is significantly correlated with the invasion and the metastasis of colorectal cancer. The aim of this study is to identify the importance of the expressions of E-cadherin and beta-catenin as a prognostic factor in T2 colorectal cancer.
Methods: Forty-five cases of primary T2 colorectal cancers were selected between February 1997 and February 2000. We evaluated the membranous expressions of E-cadherin and beta-catenin by using immunohistochemisty and analyzed the relationship with various clinico- pathologic parameters.
Results: Loss of membranous E- cadherin was significantly associated with histologic differentiation (P=0.023), vascular invasion (P＜0.001), lymphatic invasion (P＜0.001), and lymph-node metastases (P=0.001). Similar patterns were observed in the expression of beta-catenin. The correlation between the E-cadherin and the beta-catenin expressions was statistically significant (P＜0.001). In the multivariate analysis, neither the loss of expression of E-cadherin nor beta-catenin is a risk factor affecting lymph-node metastasis in T2 colorectal cancers. However, there were significant differences in the 5-year disease-free survival rates between the positive (±, ＋) and the negative (-) expression groups of E-cadherin and beta-catenin (P=0.015, 0.03).
Conclusions: This study suggests that loss of membranous expression of E-cadherin and beta-catenin molecules correlates with poor prognostic factors and indicates invasion and metastasis in T2 colorectal cancer, which, therefore, might be predictive of short survival in these patients.
키워드
이카데린; 베타카테닌; 대장직장암; 림프절 전이
E-cadherin; beta-catenin; Colorectal cancer; Lymph-node metastasis
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