´ëÀå¾Ï¿¡¼ÀÇ Hypoxia Inducible Factor-1¥á (HIF-1¥á) ¹× Vascular Endothelial Growth Factor (VEGF): ¿¹ÈÄ ¹× Á¾¾çÇ¥ÁöÀڷμÀÇ °¡´É¼º
Expression of Hypoxia-inducible Factor- 1¥á and Vascular Endothelial Growth Factor in Colon Cancer: Relationship to the Prognosis and Tumor Markers
ÃÖÀ±¿µ, Á¶Çö´ö, ¹Úµ¿±¹, ±è¼º¿ë, À̹®¼ö, ±èâȣ, Á¶¹«½Ä, ¹é¹«ÁØ,
¼Ò¼Ó »ó¼¼Á¤º¸
ÃÖÀ±¿µ ( Choi Yoon-Young )
¼øõÇâ´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
Á¶Çö´ö ( Cho Hyun-Deuk )
¼øõÇâ´ëÇб³ ÀÇ°ú´ëÇÐ º´¸®Çб³½Ç
¹Úµ¿±¹ ( Park Dong-Guk )
´Ü±¹´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
±è¼º¿ë ( Kim Sung-Yong )
¼øõÇâ´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
À̹®¼ö ( Lee Moon-Soo )
¼øõÇâ´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
±èâȣ ( Kim Chang-Ho )
¼øõÇâ´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
Á¶¹«½Ä ( Cho Moo-Sik )
¼øõÇâ´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
¹é¹«ÁØ ( Baek Moo-Jun )
¼øõÇâ´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
KMID : 0356720080240050337
Abstract
Purpose: Angiogenesis is one of the key steps in solid tumor growth and metastasis. We investigated the prognostic significance of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1¥á (HIF-1¥á
) expressions as markers of angiogenesis in colon cancer.
Methods: We retrospectively reviewed the medical records of 78 patients with colon or rectal cancer who underwent a surgical resection at Soonchunhyang University Hospital from January 2000 to December 2001, and we evaluated the expression of VEGF and HIF-1¥á in archival tumor tissues by using immunohistochemistry. We recorded the clinical and the pathological characteristics of the patients and analyzed their survival outcomes.
Results: Thirty-four (34) patients were male, and the mean age of all the patients was 66.7 years. HIF-1¥á
and VEGF were positive in 56% (44 patients) and 53% (42 patients) of the tumors, respectively. HIF-1? expression was significantly associated with several pathological parameters, such as TNM stage (P=0.001), lymph node metastasis (P=0.001). HIF-1¥á expression was also associated with VEGF expression (P=0.032). The survival of patients with HIF-1¥á
expression was worse than that of patients with no HIF-1¥á expression (P=0.036). However, VEGF expression was not associated with other pathological characteristics.
Conclusions: We suggest that, in cases of colorectal cancer, HIF-1¥á expression may be associated with expression of VEGF, progression of tumors, and poor prognosis.
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´ëÀå¾Ï;HIF-1¥á;VEGF;Ç÷°ü½Å»ý
Colorectal cancer;HIF-1¥á;VEGF;Angiogenesis
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