결장직장암과 혈관내피성장인자 발현과의 상관관계
Expression of Vascular Endothelial Growth Factor in Colorectal Cancer
조태웅, 임성철, 김성수, 민영돈, 김경종,
소속 상세정보
조태웅 ( Jo Tai-Woong )
조선대학교 의과대학 외과학교실
임성철 ( Lim Sung-Chul )
조선대학교 의과대학 내성세포연구센터
김성수 ( Kim Seong-Soo )
조선대학교 의과대학 외과학교실
민영돈 ( Min Young-Don )
조선대학교 의과대학 외과학교실
김경종 ( Kim Kyung-Jong )
조선대학교 의과대학 외과학교실
KMID : 0356720080240060433
Abstract
Purpose: The neovascularization is an essential factor for the growth of solid organ cancer and especially vascular endothelial growth factor (VEGF) has been known to the very important mediator of neovascularization. Thus, this study was searching that expression of VEGF in colorectal cancer correlate to clinicopathologic factors.
Methods: We analyzed 93 patients with sporadic colorectal cancer who underwent colectomy and their specimens were studied immunohistochemistry at Chosun University hospital from March, 2002 to November, 2005.
Results: The expression rate of VEGF was 61 cases of all (65.6%). There were no significant relation VEGF expression to age, sex and lymph node metastasis. But, VEGF expression in colon cancer was 80.5% rather than 53.8% in rectal cancer (P=0.010). Correlation with T staging, expression of VEGF was 10.0% in pT0, 62.5% in pT1, pT2 and 77.2% in pT3, pT4 (P＜0.0001), and correlation with TNM staging, expression of VEGF was 10.0% in stage 0, 63.2% in stage I, 72.0% in stage II, 73.3% in stage III and 100.0% in stage IV (P=0.001).
Conclusions: Expression of VEGF in colorectal cancer closely correlates with cancer progression and VEGF was more expressed in colon cancer than rectum.
키워드
혈관내피성장인자;결장직장암;암의 진행
VEGF;Colorectal cancer;Cancer progression
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