대장암에서 RhoA의 발현과 임상적 의의
Expression of RhoA in Colorectal Cancers and Its Clinicopathological Significance
정해일, 최윤영, 백무준, 배상호, 배상병, 정동준, 김성용, 이문수, 조무식, 김창호,
소속 상세정보
정해일 ( Jung Hae-Il )
순천향대학교 의과대학 외과학교실
최윤영 ( Choi Yoon-Young )
순천향대학교 의과대학 외과학교실
백무준 ( Baek Moo-Jun )
순천향대학교 의과대학 외과학교실
배상호 ( Bae Sang-Ho )
순천향대학교 의과대학 천안병원 외과학교실
배상병 ( Bae Sang-Byung )
순천향대학교 의과대학 내과학교실
정동준 ( Jung Dong-Jun )
순천향대학교 의과대학 병리학교실
김성용 ( Kim Sung-Yong )
순천향대학교 의과대학 외과학교실
이문수 ( Lee Moon-Soo )
순천향대학교 의과대학 외과학교실
조무식 ( Cho Moo-Sik )
순천향대학교 의과대학 외과학교실
김창호 ( Kim Chang-Ho )
순천향대학교 의과대학 외과학교실
KMID : 0356720080240060460
Abstract
Purpose: The Rho family of GTPases are involved in actin cytoskeleton organization and are associated with carcinogenesis and progression of human cancers. The clinicopathological significance of RhoA is not yet well known in the case of colorectal cancer. To investigate the expression of RhoA protein in colorectal carcinoma and to evaluate the relationship between RhoA protein expression and invasion and metastasis of colorectal cancer, we examined the expression of RhoA protein by using Western blotting and immunohistochemistry.
Methods: The protein levels of RhoA in colorectal carcinomas of surgical specimens were analyzed in 71 consecutive patients with colorectal cancers by using immunohistochemistry and Western blotting. The relationships between the protein levels of RhoA in tumor tissues and the clinicopathological features of the patients were also assessed.
Results: RhoA was highly expressed in 48 colorectal carcinomas (67.6%). There was a significant association between RhoA expression and lymph nodal status. The expression of RhoA protein was related to lymph-node metastasis (P=0.032) and advanced TNM tumor staging (P=0.020). RhoA expression had a significant prognostic value for overall survival. Kaplan-Meier plots of survival in patients with high RhoA showed that high RhoA expression was associated with a shorter overall survival. However, no association was found between RhoA and other pathologic or clinical variables, including age, gender, degree of differentiation, and presence of perineural spread.
Conclusions: The RhoA protein may be related to malignant transformation and development of colorectal caricinomas and may play an important role in the invasion and the metastasis of colorectal carcinomas.
키워드
대장암;RhoA
Colorectal carcinoma;RhoA
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