대장암에서 폐색이 예후에 미치는 영향
The Prognostic Impact of Obstructed Colorectal Cancer
정화경, 정상훈, 김재황, 심민철,
소속 상세정보
정화경 ( Jung Hwa-Kyung )
영남대학교 의과대학 외과학교실
정상훈 ( Jung Sang-Hun )
영남대학교 의과대학 외과학교실
김재황 ( Kim Jae-Hwang )
영남대학교 의과대학 외과학교실
심민철 ( Shim Min-Chul )
영남대학교 의과대학 외과학교실
KMID : 0356720080240060479
Abstract
Purpose: An obstructed colorectal cancer (OB) has a poorer survival than a non-obstructed cancer (NOB). This study examined the prognostic impact of bowel obstruction on colorectal cancer.
Methods: From December 1999 to December 2005, patients undergoing single stage operation for OB were examined prospectively. OB (n=193) was compared with a NOB (n=444) used in a primary tumor resection during the same period. 637 colorectal cancers were examined in this study.
Results: The overall operative mortality was 21 (3.3%) and the postoperative mortality was significantly higher in the OB (OB: 16, 8.3%) group than in the NOB (NOB: 5, 1.1%) group. The proportion of OB was higher in the left-colon (52.8%) than in the right colon (16.0%) and rectum (31.1%, P＜0.001). However, OB was associated with an older age (P=0.013). The proportion of advanced tumor stage was higher in OB (II: 35.8%, III: 39.5%, IV: 24.7%) than in NOB (II: 53.2%, III: 35.8%, IV: 11.0%, P＜0.001). The 5-year cancer-related survival for OB was worse than NOB (OB: 77.3%, NOB: 57.8%, P＜0.05). However, in the cases of a colorectal cancer performed curative resection (stage II and III), the survival for OB was not worse than NOB: stage II (OB: 82.8%, NOB: 92.2%, P=0.24), stage III (OB: 65.2%, NOB: 56.9%, P=0.43).
Conclusions: OB has older and more advanced disease characteristics. However, if an oncologically curative resection is performed, the survival for OB is similar to that of a NOB.
키워드
폐색성 대장암;종양관련 생존율
Obstructed colorectal cancer;Cancer related survival rate
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