결장직장암에서 종양세포 발아, 종양 결절 및 림프절 캡슐외 침습과 암 관련 유전자 발현과의 관계
The Relatioships Between Tumor-related Gene Expression and Tumor Budding, Tumor Nodule and Lymph Node Extracapsular Extension in Colorectal Cancer
강현종, 조항주, 강기창, 김기환, 강원경, 김지일, 박종경, 오승택, 김정수, 안창혁,
소속 상세정보
강현종 ( Kang Hyun-Jong )
가톨릭대학교 의과대학 외과학교실
조항주 ( Cho Hang-Joo )
가톨릭대학교 의과대학 외과학교실
강기창 ( Kang Gi-Chang )
가톨릭대학교 의과대학 외과학교실
김기환 ( Kim Kee-Hwan )
가톨릭대학교 의과대학 외과학교실
강원경 ( Kang Won-Kyung )
가톨릭대학교 의과대학 외과학교실
김지일 ( Kim Ji-Il )
가톨릭대학교 의과대학 외과학교실
박종경 ( Park Jong-Kyung )
가톨릭대학교 의과대학 외과학교실
오승택 ( Oh Seung-Tack )
가톨릭대학교 의과대학 외과학교실
김정수 ( Kim Jeong-Soo )
가톨릭대학교 의과대학 외과학교실
안창혁 ( An Chang-Hyeok )
가톨릭대학교 의과대학 외과학교실
KMID : 0356720090250010001
Abstract
Purpose : Despite the similar lymph node metastasis observed in patients with advanced colorectal cancer (CRC), there was a different clinical outcome. The relationships between tumor-related gene expression and prognostic factors such as tumor budding, tumor nodule and extracapsular extension (ECE) of lymph nodes in patients with CRC remain unclear yet. The purpose of this study was to evaluate the relationship between expression of molecular markers such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), matrix metalloproteinases (MMPs) and E-cadherin and the tumor budding, tumor nodule and ECE of lymph nodes in patients with stage III CRC.
Methods : The tissue of 87 patients with stage III CRC were investigated for expressions of molecular markers using immunohistochemical methods.
Results : VEGF and MMP-9 expression in tumor tissue were positively associated with the colorectal cancer prognostic factors such as tumor budding, tumor nodule and extracapsular lymph node extension (P<0.05). But, MMP-2, EGF and E-cadherin expression were of no value with regard to them.
Conclusion : Our results suggest that molecular markers, in particular VEGF and MMP-9, may provide additional prognostic information regarding tumor budding, ECE and tumor nodule.
키워드
결장직장암;예후인자;혈관내피성장인자;금속단백분해효소-9
Colorectal cancer;Prognostic factors;VEGF;MMP-9
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