대장암 조직에서 Matrix Matalloproteinase-2, -7, -9,-12의 발현과 임상적인 의의
The Expression and Clinical Correlations of Matrix Metalloproteinase-2, -7, -9, and -12 in Colorectal Cancer
안은정, 정순섭, 이령아, 김광호,
소속 상세정보
안은정 ( Ahn Eun-Jung )
국립의료원 외과
정순섭 ( Chung Soon-Sup )
이화여자대학교 의과대학 외과학교실
이령아 ( Lee Ryung-Ah )
이화여자대학교 의과대학 외과학교실
김광호 ( Kim Kwang-Ho )
이화여자대학교 의과대학 외과학교실
KMID : 0356720090250010026
Abstract
Purpose: Tumor invasion and metastasis are multistep phenomina, involving proteolytic degradation of extracellular matrix (ECM) and alteration of cell adhesion. It is another oncologic therapeutic strategy to block tumor invasion and metastasis through analyzing the molecules which are involved in these processes. We examined the expressions of some of matrix metalloproteinases (MMPs) in colorectal cancer and analyze the correlation with clinical factors and survival.
Methods: Fifty-five patients with colorectal cancer who underwent surgical resection were included. The expressions of the MMP-2, -7, -9, and -12 in tumor tissue and normal mucosa using RT-PCR technique was carried out. We evaluated and analyzed the correlation among these molecules, clinical characteristics, and survival.
Results: Expressions of MMP-7, -9, and -12 were significantly higher in tumor tissue than in normal mucosa (P=0.00). The expressions of MMP-2 between cancer and normal mucosa had no significant difference but it had a significant difference according to the lymph node (LN) invasion (P=0.03) in tumor tissues. Three-year overall survival was worse in patient with high expression of MMP-2 compared to low expression.
Conclusion: The expressions of MMP-7, -9, -12 in tumor tissue were higher than in normal mucosa and MMP-2 expression of tumor tissues had a significant difference according to LN invasion. MMP-2 overexpression seems to be a prognostic factor for 3-yr overall survival. But, large scale study with long term survival analysis will be needed for the prognostic significance of MMPs.
키워드
기질 금속단백분해효소;대장암
Matrix metalloproteinase;Colorectal cancer
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