대장직장암에서 p53 및 Ki-67 발현의 임상적 의의
Clinical Significance of p53 and Ki-67 Expression in Colorectal Cancer
허정욱, 김형록, 조상혁, 김영진,
소속 상세정보
허정욱 ( Huh Jung-Wook )
전남대학교 의과대학 화순전남대학교병원 외과
김형록 ( Kim Hyeong-Rok )
전남대학교 의과대학 화순전남대학교병원 외과
조상혁 ( Cho Sang-Hyuk )
전남대학교 의과대학 화순전남대학교병원 외과
김영진 ( Kim Young-Jin )
전남대학교 의과대학 화순전남대학교병원 외과
KMID : 0356720090250020107
Abstract
Purpose: This study aimed to evaluate the clinical significance of p53 and Ki-67 expressions in patients with colorectal cancer.
Methods: Immunohistochemical expressions of p53 and Ki-67 in 205 patients with colorectal cancer were examined. Results were correlated with clinical and pathological parameters.
Results: Overexpression of p53 was significantly associated with a proximal location of the tumor (P=0.031) and with lymph node involvement (P=0.030); however, Ki-67 expression was not correlated with any of the clinicopathological variables.Positive p53 staining was significantly associated with a higher level of Ki-67 (P=0.009).
Conclusions: Overexpression of p53 was strongly correlated with lymph node metastasis in colorectal cancer; thus, p53 may be used as a possible prognostic marker in patients with colorectal cancer.
키워드
p53;Ki-67;대장암
p53;Ki-67;Colorectal cancer
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