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Malignancy Associated with Inflammatory Bowel Disease
½ÅÀǼ·, ±èÂù¿í, À¯Ã¢½Ä, À±»ó³², ÀÓ¼®º´, ¼ÛÁؼ±, ±èÁøõ, ¹ÚÁø¼®, Á¤±¤¿ë,
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½ÅÀǼ· ( Shin Ui-Sup )
¿ï»ê´ëÇб³ ÀÇ°ú´ëÇÐ ¼¿ï¾Æ»êº´¿ø ¿Ü°úÇб³½Ç
±èÂù¿í ( Kim Chan-Wook )
¿ï»ê´ëÇб³ ÀÇ°ú´ëÇÐ ¼¿ï¾Æ»êº´¿ø ¿Ü°úÇб³½Ç
À¯Ã¢½Ä ( Yu Chang-Sik )
¿ï»ê´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
À±»ó³² ( Yoon Sang-Nam )
¿ï»ê´ëÇб³ ÀÇ°ú´ëÇÐ ¼¿ï¾Æ»êº´¿ø ¿Ü°úÇб³½Ç
ÀÓ¼®º´ ( Lim Seok-Byung )
¿ï»ê´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
¼ÛÁؼ± ( Song Joon-Seon )
¿ï»ê´ëÇб³ ÀÇ°ú´ëÇÐ ¼¿ï¾Æ»êº´¿ø º´¸®°ú
±èÁøõ ( Kim Jin-Cheon )
¿ï»ê´ëÇб³ ÀÇ°ú´ëÇÐ ¼¿ï¾Æ»êº´¿ø ´ëÀåÇ×¹®¿Ü°úÇб³½Ç
¹ÚÁø¼® ( Park Jin-Seok )
¿ï»ê´ëÇб³ ÀÇ°ú´ëÇÐ ¼¿ï¾Æ»êº´¿ø ´ëÀåÇ×¹®¿Ü°úÇб³½Ç
Á¤±¤¿ë ( Jung Kwang-Yong )
¿ï»ê´ëÇб³ ÀÇ°ú´ëÇÐ ¼¿ï¾Æ»êº´¿ø ´ëÀåÇ×¹®¿Ü°úÇб³½Ç
KMID : 0356720090250030150
Abstract
Purpose: As the number of patients with inflammatory bowel disease (IBD) has steadily increased in Korea, IBD-associated cancers are expected to increase in number. This study investigated the clinical features of intestinal cancer in patients with IBD.
Methods: One hundred five patients with ulcerative colitis (UC) and 270 patients with Crohn¡¯s disease (CD) under the care of the Department of Colon and Rectal Surgery, Asan Medical Center, between December 1989 and January 2009 were reviewed retrospectively.
Results: Ten patients of the 105 with UC and 5 patients of the 270 with CD were found to have intestinal cancer. The mean age was 45 yr (¡¾8.8), and the mean duration of IBD at the time of diagnosis of the cancer was 12.6 yr (¡¾6.0). Six of the 15 cancer patients had no history of treatment for IBD of more than 3 mo before diagnosis of the cancer. Eleven cancers were located in the rectum (7 in UC, 4 in CD), including 1 case of synchronous cancer. One case of small bowel cancer was found in a patient with small bowel CD. Four cases involved a mucinous adenocarcinoma. Eight of the 12 cases of an adenocarcinoma of the colon and rectum were advanced stage.
Conclusions: IBD-associated intestinal cancers were found at a relatively young age, were diagnosed at an advanced stage, and had a higher proportion of mucinous adenocarcinomas than in sporadic cancer. Considering the increasing incidence of IBD and the expected increase in the number of IBD-associated cancer in Korea, every effort should be made to prevent intestinal cancer in patients with IBD and to detect it early.
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Inflammatory bowel dieseas;Colorectal cancer;Mucinous adenocarcinoma;Lymphoma;Squamous cell carcinoma
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