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Clinicopathologic Analysis of Gastrointestinal Stromal Tumors of the Colon and Rectum
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ÃÖ°æ¾Ö ( Choi Kyung-Ae )
±¹¹Î°Ç°º¸Çè°ø´Ü Àϻ꺴¿ø ¿Ü°ú
¹é½ÂÇõ ( Paik Seung-Hyuk )
¿¬¼¼´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
±èÁø¼ö ( Kim Jin-Soo )
¿¬¼¼´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
¹Îº´¼Ò ( Min Byung-Soh )
¿¬¼¼´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
ÃÖÀ±Á¤ ( Choi Yoon-Jung )
±¹¹Î°Ç°º¸Çè°ø´Ü Àϻ꺴¿ø º´¸®°ú
±è³²±Ô ( Kim Nam-Kyu )
¿¬¼¼´ëÇб³ ÀÇ°ú´ëÇÐ ¿Ü°úÇб³½Ç
±è¼Àü ( Kim Seo-Jeon )
±¹¹Î°Ç°º¸Çè°ø´Ü Àϻ꺴¿ø ¿Ü°ú
KMID : 0356720090250050323
Abstract
Purpose: This study¡¯s aim is to investigate the clinicopathologic characteristics of colorectal gastrointestinal stromal tumors (GISTs) and to evaluate the result of those tumors.
Methods: We retrospectively reviewed 22 patients who had been diagnosed with primary colorectal GISTs and who had undergone a surgical resection between October 1996 and July 2008.
Results: Colorectal GISTs accounted for 0.28% of all colorectal malignancies and 7.7% of all GISTs. Rectal GISTs (19, 86.4%) were more common than colonic GISTs (3, 13.6%). According to the National Institute of Health¡¯s (NIH) grading system, there were 1 (4.5%) very low, 5 (22.7%) low, 4 (18.2%) intermediate, and 12 (54.6%) high-risk tumors. The disease recurred in 7 patients (1 with intermediate risk and 6 with high risk). Recurrence sites were the liver (42.9%), the peritoneum (71.5%), and the lymph nodes (14.3%). Adjuvant imatinib therapy and/or radiation therapy were done for patients with microscopically positive margins of resection and high risk, of which one experienced a recurrence at 95 months after surgery. The five-year recurrence rates were 0% in the very-low-grade and low-grade groups, 33.3% in the intermediate-grade group, and 37.5% in the high-grade group. The five-year overall survival rates were 100% in the very-low-grade and low-grade groups, 66.7% in the intermediate-grade group, and 62.5% in the high-grade group.
Conclusion: Poor prognosis of colorectal GISTs was closely related to the tumor¡¯s histologic grade and size. Integrating surgery, molecular therapy, and radiation therapy might improve outcomes, but further study with more cases is needed.
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GISTs;Colorectum;Treatment ;Recurrence
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