Concurrent Large Cell Neuroendocrine Carcinoma and Adenocarcinoma of the Ascending Colon: A Case Report
±è¿ä³ª, ¹ÚÈ£¼º, Àå±ÔÀ±, ¹®¿ì¼º, À̵¿±Ù, ÀÌÈ£, À̹ηÎ, ±è°æ·Ä,
¼Ò¼Ó »ó¼¼Á¤º¸
±è¿ä³ª ( Kim Yo-Na )
Chonbuk National University Medical School Department of Pathology
¹ÚÈ£¼º ( Park Ho-Sung )
Chonbuk National University Medical School Department of Pathology
Àå±ÔÀ± ( Jang Kyu-Yun )
Chonbuk National University Medical School Department of Pathology
¹®¿ì¼º ( Moon Woo-Sung )
Chonbuk National University Medical School Department of Pathology
À̵¿±Ù ( Lee Dong-Geun )
Chonbuk National University Medical School Department of Pathology
ÀÌÈ£ ( Lee Ho )
Chonbuk National University Medical School Department of Forensic Medicine
À̹ηΠ( Lee Min-Ro )
Chonbuk National University Medical School Department of Surgery
±è°æ·Ä ( Kim Kyung-Ryoul )
National Institute of Science Investigation Department of Forensic Medicine
KMID : 0356720110270030157
Abstract
Large cell neuroendocrine carcinomas of the colon are rare and represent only a small percentage of all colonic endocrine tumors. Here, we report a case of a colonic large cell neuroendocrine carcinomas concurrent with a colonic adenocarcinoma. A 70-year-old man presented with acute abdominal pain. A spiral computed tomography scan of the abdomen revealed eccentric wall thickening on the ascending colon. An explorative laparotomy and a right hemicolectomy were performed. Grossly, two separated masses were observed in the proximal ascending colon. One was a 7.4 ¡¿ 5.1 cm ulcerative fungating lesion, and the other was a 2.8 ¡¿ 1.9 cm polypoid lesion. Microscopically, the ulcerative fungating lesion showed a well-differentiated neuroendocrine morphology with necrosis and increased mitosis. Most of the tumor cells had large, vesicular nuclei with eosinophilic nucleoli, variable amounts of eosinophilic cytoplasm, and immunoreactivity for chromogranin A and synaptophysin. The polypoid lesion was a well-differentiated adenocarcinoma that had invaded the submucosa. We diagnosed these lesions as a concurrent large cell neuroendocrine carcinoma and an adenocarcinoma of the ascending colon.
Å°¿öµå
Colon neoplasms; Carcinoma; Neuroendocrine; Adenocarcinoma
¿ø¹® ¹× ¸µÅ©¾Æ¿ô Á¤º¸
µîÀçÀú³Î Á¤º¸