Correlation between Liver Metastases and the Level of PRL-3 mRNA Expression in Patients with Primary Colorectal Cancer
김남원, 주종우, 안태성, 손명원, 배상호, 이문수, 김창호, 백무준, 김창진, 정동준,
소속 상세정보
김남원 ( Kim Nam-Won )
순천향대학교 의과대학 외과학교실
주종우 ( Chu Chong-Woo )
부산대학교 의과대학 양산병원 외과학교실
안태성 ( Ahn Tae-Sung )
Soonchunhyang University College of Medicine Department of Surgery
손명원 ( Son Myoung-Won )
순천향대학교 의과대학 외과학교실
배상호 ( Bae Sang-Ho )
순천향대학교 의과대학 외과학교실
이문수 ( Lee Moon-Soo )
순천향대학교 의과대학 외과학교실
김창호 ( Kim Chang-Ho )
순천향대학교 의과대학 외과학교실
백무준 ( Baek Moo-Jun )
순천향대학교 의과대학 외과학교실
김창진 ( Kim Chang-Jin )
순천향대학교 의과대학 병리학교실
정동준 ( Jung Dong-Jun )
순천향대학교 의과대학 병리학교실
KMID : 0356720110270050231
Abstract
Purpose: Phosphatase of regenerating liver-3 (PRL-3) has been associated with metastasis promotion. However, clinical applications of this association have not yet been clearly demonstrated. In this study, we evaluated the relation of PRL-3 mRNA level in primary colorectal cancer to the corresponding stage and to other clinicopathologic factors.
Methods: Two hundred forty-five patients with histologically-proven colorectal cancer underwent surgery between January 2004 and December 2006. RNA was extracted and cDNA was prepared by using reverse transcription. Quantification of PRL-3 was done using a real-time polymerase chain reaction.
Results: Eighty-six cases with well-preserved specimens were enrolled: 53 males and 33 females. The mean age was 63.4 years. According to tumour node metastasis (TNM) stage of the American Joint Committee on Cancer (AJCC), stage I was 11 cases, stage II was 38 cases, stage III was 23 cases, and stage IV was 14 cases. Among stage IV cases, one case was combined with liver and lung metastases, and one case was combined with liver metastases and peritoneal dissemination. The remaining stage IV patients were combined with only liver metastases. There was a significant correlation in PRL-3 mRNA expression between primary colorectal cancer and corresponding tumor stage. PRL-3 mRNA expression was increased in the liver metastases cases. Lymphatic and vascular invasion were significantly related with PRL-3 mRNA levels.
Conclusion: Advanced stage prediction may be obtained by measuring the level of PRL-3 mRNA expression in primary colorectal cancer. Especially, the risk of liver metastases may be predicted by measuring the level of PRL-3 mRNA expression in primary colorectal cancer. Further study is required to confirm these preliminary results.
키워드
PTP4A3 protein;human;Real-time polymerase chain reaction;Colorectal neoplasms;Neoplasm Metastasis
원문 및 링크아웃 정보
등재저널 정보