Oxaliplatin-induced Pulmonary Fibrosis: Two Case Reports
유춘근, 정은주, 김강미, 김수란, 황대용,
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유춘근 ( Ryu Chun-Geun )
건국대학교 의학전문대학원 외과학교실
정은주 ( Jung Eun-Joo )
건국대학교 의학전문대학원 외과학교실
김강미 ( Kim Gang-Mi )
건국대학교 의과대학 외과학교실
김수란 ( Kim Su-Ran )
건국대학교 의과대학 외과학교실
황대용 ( Hwang Dae-Yong )
건국대학교 의과대학 외과학교실
KMID : 0356720110270050266
Abstract
Oxaliplatin with infusional 5-fluorouracil plus leucovorin (FOLFOX regimen) is the one of the standard chemotherapy regimens for treating a colorectal carcinoma. The most common side effects include neutropenia, diarrhea, vomiting and peripheral neuropathy, and these are moderate and manageable. However, pulmonary toxicity is rarely reported to be associated with the FOLFOX regimen. Moreover, there is no established guideline for the management of this side effect. Here, along with a literature review, we report two cases of rapidly developing pulmonary fibrosis related to the use of the FOLFOX regimen in patients with colorectal carcinomas.
키워드
Oxaliplatin;Toxicity;Pulmonary fibrosis.
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