Stromal-cell-derived Factor 1-α Promotes Tumor Progression in Colorectal Cancer
박세준, 안태성, 조성우, 김창진, 정동준, 손명원, 배상호, 신응진, 이문수, 김창호, 백무준,
소속 상세정보
박세준 ( Park Se-Jun )
Soonchunhyang University College of Medicine Department of Surgery
안태성 ( Ahn Tae-Sung )
Soonchunhyang University College of Medicine Department of Surgery
조성우 ( Cho Sung-Woo )
Soonchunhyang University College of Medicine Department of Surgery
김창진 ( Kim Chang-Jin )
Soonchunhyang University College of Medicine Department of Pathology
정동준 ( Jung Dong-Jun )
Soonchunhyang University College of Medicine Department of Pathology
손명원 ( Son Myoung-Won )
Soonchunhyang University College of Medicine Department of Surgery
배상호 ( Bae Sang-Ho )
Soonchunhyang University College of Medicine Department of Surgery
신응진 ( Shin Eung-Jin )
Soonchunhyang University Bucheon Hospital Department of Surgery
이문수 ( Lee Moon-Soo )
Soonchunhyang University College of Medicine Department of Surgery
김창호 ( Kim Chang-Ho )
Soonchunhyang University College of Medicine Department of Surgery
백무준 ( Baek Moo-Jun )
Soonchunhyang University College of Medicine Department of Surgery
KMID : 0356720120280010027
Abstract
Purpose: Although stromal-cell-derived factor (SDF)-1α is suggested to be involved in tumorigenicity and tumor angiogenesis, the clinicopathological significance of its expression in colorectal cancers is not fully understood. We examined SDF-1α expression in colorectal cancers and investigated its relationship to clinicopathological features such as tumor staging, lymph-node metastasis, vascular invasion (VI), lymphatic invasion (LI) and neural invasion (NI).
Methods: Specimens of 83 primary colorectal cancers were examined immunohistochemically, and the relationships between clinicopathological features and SDF-1α expression were analyzed. To compare the expressions between the normal colon tissue and colorectal cancer tissues, we performed Western blot analyses.
Results: According to the Western blot analyses, SDF-1α was more highly expressed in colorectal carcinoma tissues than in normal colonic mucosa (20/21). According to the immunohistochemical stain, SDF-1α was associated with nodal status, distant metastasis, tumor staging, VI and LI. SDF-1α expression had a significant prognostic value for overall survival. Kaplan-Meier plots of survival in patients with high SDF-1α showed that high SDF-1α expression was associated with a shorter overall survival. However, no association was found between SDF-1α expression and other pathologic or clinical variables, including age, gender, degree of differentiation, and presence of perineural invasion.
Conclusion: The expression of SDF-1α might be associated with tumor progression in colorectal cancer. Inhibition of SDF-1α could be a therapeutic option in colorectal cancer patients.
키워드
Colorectal neoplasms; Survival; Prognostic factor; SDF-1α; Chemokine CXCL12
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