Oncologic Outcomes and Risk Factors for Recurrence after Tumor-specific Mesorectal Excision of Rectal Cancer: 782 Cases
김삼희, 배기범, 김정민, 신재호, 안민성, 하태균, Ryu Sung-Mok, 김광희, 김태현, 최창수, 신진용, 오민경, 백승훈, 홍관희,
소속 상세정보
김삼희 ( Kim Sam-Hee )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
배기범 ( Bae Ki-Beom )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
김정민 ( Kim Jung-Min )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
신재호 ( Shin Jae-Ho )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
안민성 ( An Min-Sung )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
하태균 ( Ha Tae-Geun )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
( Ryu Sung-Mok )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
김광희 ( Kim Kwang-Hee )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
김태현 ( Kim Tae-Hyeon )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
최창수 ( Choi Chang-Soo )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
신진용 ( Shin Jin-Yong )
Inje University Haeundae Paik Hospital Department of Surgery
오민경 ( Oh Min-Kyung )
Inje University College of Medicine Clinical Trial Center in Pharmacology Department of Surgery
백승훈 ( Baek Seung-Hun )
Inje University College of Medicine Clinical Trial Center in Pharmacology Department of Surgery
홍관희 ( Hong Kwan-Hee )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
KMID : 0356720120280020100
Abstract
Purpose: The aim of this study was to analyze the oncologic outcomes and the risk factors for recurrence after a tumor-specific mesorectal excision (TSME) of resectable rectal cancer in a single institution.
Methods: A total of 782 patients who underwent a TSME for resectable rectal cancer between February 1995 and December 2005 were enrolled retrospectively. Oncologic outcomes included 5-year cancer-specific survival and its affecting factors, as well as risk factors for local and systemic recurrence.
Results: The 5-year cancer-specific survival rate was 77.53% with a mean follow-up period of 61 ± 31 months. The overall local and systemic recurrence rates were 9.2% and 21.1%, respectively. The risk factors for local recurrence were pN stage (P = 0.015), positive distal resection margin, and positive circumferential resection margin (P < 0.001). The risk factors for systemic recurrence were pN stage (P < 0.001) and preoperative carcinoembryonic antigen level (P = 0.005). The prognostic factors for cancer-specific survival were pT stage (P < 0.001), pN stage (P < 0.001), positive distal resection margin (P = 0.005), and positive circumferential resection margin (P = 0.016).
Conclusion: The oncologic outcomes in our institution after a TSME for patients with resectable rectal cancer were similar to those reported in other recent studies, and we established the risk factors that could be crucial for the planning of treatment and follow-up.
키워드
Rectal neoplasms; Colorectal cancer recurrence; Oncologic outcome; Tumor-specific mesorectal excision
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