Does T3 Subdivision Correlate with Nodal or Distant Metastasis in Colorectal Cancer?
유홍열, 신루미, 하헌균, 오흥권, 정승용, 박규주, 강경훈, 김우호, 박재갑,
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유홍열 ( Yoo Hong-Yeol )
Seoul National University College of Medicine Department of Surgery
신루미 ( Shin Ru-Mi )
Seoul National University College of Medicine Department of Surgery
하헌균 ( Ha Heon-Kyun )
Seoul National University College of Medicine Department of Surgery
오흥권 ( Oh Heung-Kwon )
Seoul National University College of Medicine Department of Surgery
정승용 ( Jeong Seung-Yong )
Seoul National University College of Medicine Department of Surgery
박규주 ( Park Kyu-Joo )
Seoul National University College of Medicine Department of Surgery
강경훈 ( Kang Gyeong-Hoon )
Seoul National University College of Medicine Department of Pathology
김우호 ( Kim Woo-Ho )
Seoul National University College of Medicine Department of Pathology
박재갑 ( Park Jae-Gahb )
Seoul National University College of Medicine Department of Surgery
KMID : 0356720120280030160
Abstract
Purpose: We analyzed the clinical data of T3 colorectal cancer patients to assess whether T3 subdivision correlates with node (N) or metastasis (M) staging and stage-independent factors.
Methods: Five hundred fifty-five patients who underwent surgery for primary colorectal cancer from January 2003 to December 2009 were analyzed for T3 subdivision. T3 subdivision was determined by the depth of invasion beyond the outer border of the proper muscle (T3a, <1 mm; T3b, 1 to 5 mm; T3c, >5 to 15 mm; T3d, >15 mm). We investigated the correlation between T3 subdivision and N, M staging and stage-independent prognostic factors including angiolymphatic invasion (ALI), venous invasion (VI) and perineural invasion (PNI).
Results: The tumors of the 555 patients were subclassified as T3a in 86 patients (15.5%), T3b in 209 patients (37.7%), T3c in 210 patients (37.8%) and T3d in 50 patients (9.0%). The nodal metastasis rates were 39.5% for T3a, 56.5% for T3b, 75.7% for T3c and 74.0% for T3d. The distant metastasis rates were 7.0% for T3a 9.1% for T3b, 27.1% for T3c and 40.0% for T3d. Both N and M staging correlated with T3 subdivision (Spearman’s rho = 0.288, 0.276, respectively; P < 0.001). Other stage-independent prognostic factors correlated well with T3 subdivision (Spearman’s rho = 0.250, P < 0.001 for ALI; rho = 0.146, P < 0.001 for VI; rho = 0.271, P < 0.001 for PNI).
Conclusion: Subdivision of T3 colorectal cancer correlates with nodal and metastasis staging. Moreover, it correlates with other prognostic factors for colorectal cancer.
키워드
T3 subdivision; Colorectal neoplasms; Neoplasm staging
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