Incidence and Multiplicities of Adenomatous Polyps in TNM Stage I Colorectal Cancer in Korea
홍영상, 정은주, 유춘근, 김강미, 김수란, 홍성노, 황대용,
소속 상세정보
홍영상 ( Hong Young-Sang )
Konkuk University School of Medicine Department of Surgery
정은주 ( Jung Eun-Joo )
Konkuk University School of Medicine Department of Surgery
유춘근 ( Ryu Chun-Geun )
Konkuk University School of Medicine Department of Surgery
김강미 ( Kim Gang-Mi )
Konkuk University School of Medicine Department of Surgery
김수란 ( Kim Su-Ran )
Konkuk University School of Medicine Department of Surgery
홍성노 ( Hong Sung-Noh )
Konkuk University School of Medicine Department of Internal Medicine
황대용 ( Hwang Dae-Yong )
Konkuk University School of Medicine Department of Surgery
KMID : 0356720120280040213
Abstract
Purpose: In recent years, the incidence of early-stage colorectal cancer (CRC) has markedly increased in the population within the Republic of Korea. The aim of this study was to evaluate the clinicopathologic features of adenomatous polyps in TNM stage I CRC patients and in the general population.
Methods: Between March 2003 and September 2009, 168 patients with stage I CRC were enrolled in this study. In addition, the records of 4,315 members of the general population without CRC, as determined by colonoscopy during a health check-up, were reviewed.
Results: Of the 168 patients with stage I CRC, 68 (40.5%) had coexisting colorectal adenomatous polyps and of the 4,315 members of the general population, 1,112 (26.0%) had coexisting adenomatous polyps (P = 0.006). The prevalences of adenomatous polyp multiplicity in early CRC and in the general population were 32% and 15%, respectively (P = 0.023). Patients with coexisting adenomatous polyps had a higher frequency of tubulovillous or villous adenomas than members of the general population with polyps (7.5% vs. 2.0%, P = 0.037). Furthermore, a subgroup analysis showed that the occurrence (44% vs. 34%, P = 0.006) and the multiplicity (32% vs. 15%, P = 0.023) of adenomatous polyps were greater for T2 than T1 cancer.
Conclusion: The prevalence and the multiplicity of adenomatous polyps in TNM stage I CRC is higher than it is in the general population. The findings of this study suggest that depth of invasion of early stage CRC affects the prevalence and the number of adenomatous polyps in the remaining colon and rectum.
키워드
Colorectal carcinoma; Adenomatous polyp; Stage I; Colonoscopy
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