Expression of Secreted Protein Acidic and Rich in Cysteine in the Stroma of a Colorectal Carcinoma is Associated With Patient Prognosis
김정연, 정동준, 김형주, 박두산, 박소용, 이숙영, 조현덕, 안태성, 이문수, 백무준, 배상병, 이성수,
소속 상세정보
김정연 ( Kim Jeong-Yeon )
Soonchunhyang University College of Medicine Department of Pathology
정동준 ( Jeong Dong-Jun )
Soonchunhyang University College of Medicine Department of Pathology
김형주 ( Kim Hyung-Ju )
Soonchunhyang University College of Medicine Department of Pathology
박두산 ( Park Doo-San )
Soonchunhyang University College of Medicine Department of Pathology
박소용 ( Park So-Yong )
Soonchunhyang University College of Medicine Department of Pathology
이숙영 ( Lee Sook-Young )
Soonchunhyang University College of Medicine Department of Pathology
조현덕 ( Cho Hyun-Deuk )
Soonchunhyang University College of Medicine Department of Pathology
안태성 ( Ahn Tae-Sung )
Soonchunhyang University College of Medicine Department of Surgery
이문수 ( Lee Moon-Soo )
Soonchunhyang University College of Medicine Department of Surgery
백무준 ( Baek Moo-Jun )
Soonchunhyang University College of Medicine Department of Surgery
배상병 ( Bae Sang-Byung )
Soonchunhyang University College of Medicine Department of Internal Medicine
이성수 ( Lee Sung-Soo )
Soonchunhyang University College of Medicine Department of Preventive Medicine
KMID : 0356720130290030093
Abstract
Purpose: Secreted protein acidic and rich in cysteine (SPARC), also known as osteonectin or basement-membrane-40 (BM-40), is a member of a family of matricellular proteins, whose functions are to modulate cell-matrix interactions, growth and angiogenesis in colorectal cancer. In this study, the expression of SPARC was evaluated and its correlations with clinicopathological parameters were investigated.
Methods: The researchers analyzed the expression patterns of SPARC by using immunohistochemistry in 332 cases of colorectal cancer of tissue microarray. The clinicopathological characteristics were defined by using the TNM criteria of the Union for International Cancer Control. Clinicopathological factors such as age, sex, histologic type of the tumor, pathologic tumor stage, TNM stage, and lymphovascular invasion were evaluated according to the SPARC expression.
Results: The hazard ratios expressing SPARC in tumor cells, in the stroma, and in both tumor cells and the stroma were 2.10 (P = 0.036), 3.27 (P = 0.003) and 2.12 (P = 0.038), respectively. Patient survival was decreased in patient expressing SPARC in the stroma, and this result showed statistical significance (P = 0.016).
Conclusion: These findings suggest that SPARC expression in a tumor and in the stroma correlates with disease progression and may be used as a prognostic marker for colorectal cancer.
키워드
SPARC;Osteonectin;Colorectal neoplasms;Prognosis
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