Prognostic Significance of the Decreased Rate of Perioperative Serum Carcinoembryonic Antigen Level in the Patients With Colon Cancer After a Curative Resection
Jung Tae-Doo, 유종한, 이민재, Park Ha-Kyung, 신재호, 안민성, 하태권, 김광희, 배기범, 김태현, 최창수, 홍관희, 오민경,
소속 상세정보
( Jung Tae-Doo )
Inje University Busan Paik Hospital Department of Surgery
유종한 ( Yoo Jong-Han )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
이민재 ( Lee Min-Jae )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
( Park Ha-Kyung )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
신재호 ( Shin Jae-Ho )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
안민성 ( An Min-Sung )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
하태권 ( Ha Tae-Kwun )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
김광희 ( Kim Kwang-Hee )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
배기범 ( Bae Ki-Beom )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
김태현 ( Kim Tae-Hyeon )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
최창수 ( Choi Chang-Soo )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
홍관희 ( Hong Kwan-Hee )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
오민경 ( Oh Min-Kyung )
Inje University College of Medicine Clinical Trial Center in Pharmacology
KMID : 0356720130290030115
Abstract
Purpose: The serum level of carcinoembryonic antigen (CEA) is a clinical prognostic factor in the follow-up evaluation of patients with colon cancer. We aimed to evaluate the prognostic significance of the rate of decrease of the perioperative serum CEA level in patients with colon cancer after a curative resection.
Methods: A total of 605 patients who underwent a curative resection for colon cancer between January 2000 and December 2007 were enrolled retrospectively. The rate of decrease was calculated using the following equation: ([preoperative CEA - postoperative CEA]/[preoperative CEA] ×100).
Results: In the group with a preoperative serum CEA level of >5 ng/mL, the normalized group with a postoperative serum CEA level of ≤5 ng/mL showed a better overall survival (OS) rate and disease-free survival (DFS) rate than those of the non-normalized group (P ≤ 0.0001). The "cutoff values" of the rate of decrease in the perioperative serum CEA that determined the OS and the DFS were 48.9% and 50.8%, respectively. In the multivariate analysis of preoperative serum CEA levels >5 ng/mL, the prognostic factors for the OS and the DFS were the cutoff value (P < 0.0001) and the pN stage (P < 0.0001).
Conclusion: A rate of decrease of more than 50% in the perioperative serum CEA level, as well as the normalization of the postoperative serum CEA level, may be useful factors for determining a prognosis for colon cancer patients with high preoperative CEA levels.
키워드
Colon neoplasms;Carcinoembryonic antigen;Prognostic factor
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