A Phase II Study of Additional Four-Week Chemotherapy With Capecitabine During the Resting Periods After Six-Week Neoadjuvant Chemoradiotherapy in Patients With Locally Advanced Rectal Cancer
이경하, 송민상, Park Jun-Boem, 김진수, 강대영, 김지연,
소속 상세정보
이경하 ( Lee Kyung-Ha )
Chungnam National University Hospital Department of Surgery
송민상 ( Song Min-Sang )
Chungnam National University Hospital Department of Surgery
( Park Jun-Boem )
Chungnam National University Hospital Department of Surgery
김진수 ( Kim Jin-Soo )
Chungnam National University Hospital Department of Surgery
강대영 ( Kang Dae-Young )
Chungnam National University Hospital Department of Pathology
김지연 ( Kim Ji-Yeon )
Chungnam National University Hospital Department of Surgery
KMID : 0356720130290050192
Abstract
Purpose: The aim of this study is to evaluate the efficacy and the safety of additional 4-week chemotherapy with capecitabine during the resting periods after a 6-week neoadjuvant chemoradiotherapy (NCRT) in patients with locally advanced rectal cancer.
Methods: Radiotherapy was delivered to the whole pelvis at a total dose of 50.4 Gy for 6 weeks. Oral capecitabine was administered at a dose of 825 mg/m2 twice daily for 10 weeks. Surgery was performed 2-4 weeks following the completion of chemotherapy.
Results: Between January 2010 and September 2011, 44 patients were enrolled. Forty-three patients underwent surgery, and 41 patients completed the scheduled treatment. Pathologic complete remission (pCR) was noted in 9 patients (20.9%). T down-staging and N down-staging were observed in 32 patients (74.4%) and 33 patients (76.7%), respectively. Grade 3 to 5 toxicity was noted in 5 patients (11.4%). The pCR rate was similar with the pCR rates obtained after conventional NCRT at our institute and at other institutes.
Conclusion: This study showed that additional 4-week chemotherapy with capecitabine during the resting periods after 6-week NCRT was safe, but it was no more effective than conventional NCRT.
키워드
Rectal neoplasms; Neoadjuvant therapy; Chemoradiotherapy; Capecitabine
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