Association Between a Close Distal Resection Margin and Recurrence After a Sphincter-Saving Resection for T3 Mid- or Low-Rectal Cancer Without Radiotherapy
한재웅, Park Ha-Kyung, 신재호, 안민성, 하태권, 김광희, 배기범, 김태현, 최창수, 오상훈, 오민경, 강미선, 홍관희,
소속 상세정보
한재웅 ( Han Jae-Woong )
Inje University College of Medicine Inje University Pusan Paik Hospital Department of Surgery
( Park Ha-Kyung )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
신재호 ( Shin Jae-Ho )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
안민성 ( An Min-Sung )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
하태권 ( Ha Tae-Kwun )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
김광희 ( Kim Kwang-Hee )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
배기범 ( Bae Ki-Beom )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
김태현 ( Kim Tae-Hyun )
Inje University College of Medicine Inje University Pusan Paik Hospital Department of Surgery
최창수 ( Choi Chang-Soo )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
오상훈 ( Oh Sang-Hoon )
Inje University College of Medicine Pusan Paik Hospital Department of Surgery
오민경 ( Oh Min-Kyung )
Inje University College of Medicine Clinical Trial Center in Pharmacology
강미선 ( Kang Mi-Seon )
Inje University College of Medicine Busan Paik Hospital Department of Pathology
홍관희 ( Hong Kwan-Hee )
Inje University College of Medicine Busan Paik Hospital Department of Surgery
KMID : 0356720130290060231
Abstract
Purpose: To maintain the patient’s quality of life, surgeons strive to preserve the sphincter during rectal cancer surgery. This study evaluated the oncologic safety of a sphincter-saving resection with a distal resection margin (DRM) <1 cm without radiotherapy in T3, mid- or low-rectal cancer.
Methods: This retrospective study enrolled 327 patients who underwent a sphincter-saving resection for proven T3 rectal cancer located <10 cm from the anal verge and without radiotherapy between January 1995 and December 2011. The oncologic outcomes included the 5-year cancer-specific survival, the local recurrence, and the systemic recurrence rates.
Results: In groups A (DRM ≤1 cm) and B (DRM >1 cm), the 5-year cancer-specific survival rates were 81.57% and 80.03% (P = 0.8543), the 5-year local recurrence rates were 6.69% and 9.52% (P = 0.3981), and the 5-year systemic recurrence rates were 19.46% and 23.11% (P = 0.5750), respectively.
Conclusion: This study showed that the close DRM itself should not be a contraindication for a sphincter-saving resection for T3 mid- or low-rectal cancer without radiotherapy. However, a prospective randomized controlled trial including the effect of adjuvant therapy will be needed
키워드
Rectal neoplasms; Distal resection margin; Recurrence
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