Role of β1-Integrin in Colorectal Cancer: Case-Control Study
오보영, 김광호, 정순섭, Hong Kyoung-Sook, 이령아,
소속 상세정보
오보영 ( Oh Bo-Young )
Ewha Womans University School of Medicine Department of Surgery
김광호 ( Kim Kwang-Ho )
Ewha Womans University School of Medicine Department of Surgery
정순섭 ( Chung Soon-Sup )
Ewha Womans University College of Medicine Department of Surgery
( Hong Kyoung-Sook )
Ewha Womans University School of Medicine Department of Surgery
이령아 ( Lee Ryung-Ah )
Ewha Womans University School of Medicine Department of Surgery
KMID : 0356720140300020061
Abstract
Purpose: In the metastatic process, interactions between circulating tumor cells (CTCs) and the extracellular matrix or surrounding cells are required. β1-Integrin may mediate these interactions. The aim of this study was to investigate whether β1-integrin is associated with the detection of CTCs in colorectal cancer.
Methods: We enrolled 30 patients with colorectal cancer (experimental group) and 30 patients with benign diseases (control group). Blood samples were obtained from each group, carcinoembryonic antigen (CEA) mRNA for CTCs marker and β1-integrin mRNA levels were estimated by using reverse transcription-polymerase chain reaction, and the results were compared between the two groups. In the experimental group, preoperative results were compared with postoperative results for each marker. In addition, we analyzed the correlation between the expressions of β1-integrin and CEA.
Results: CEA mRNA was detected more frequently in colorectal cancer patients than in control patients (P = 0.008). CEA mRNA was significantly reduced after surgery in the colorectal cancer patients (P = 0.032). β1-Integrin mRNA was detected more in colorectal cancer patients than in the patients with benign diseases (P < 0.001). In colorectal cancer patients, expression of β1-integrin mRNA was detected more for advanced-stage cancer than for early-stage cancer (P = 0.033) and was significantly decreased after surgery (P < 0.001). In addition, expression of β1-integrin mRNA was significantly associated with that of CEA mRNA in colorectal cancer patients (P = 0.001).
Conclusion: In conclusion, β1-integrin is a potential factor for forming a prognosis following surgical resection in colorectal cancer patients. β1-Integrin may be a candidate for use as a marker for early detection of micrometastatic tumor cells and for monitoring the therapeutic response in colorectal cancer patients.
키워드
β1-Integrin; Circulating tumor cells; Carcinoembryonic antigen; Colorectal cancer
원문 및 링크아웃 정보
등재저널 정보