한국인 갑상선 유두상암종 환자에서 XPC-PAT 유전자 다형
XPC-PAT Polymorphism in Korean Thyroid Papillary Carcinoma
태경, 이근영, 김희옥, 이용섭, 이형석, 안유헌,
소속 상세정보
태경 ( Tae Kyung )
한양대학교 의과대학 이비인후-두경부외과학교실
이근영 ( Lee Keun-Young )
한양대학교 의과대학 이비인후과학교실
김희옥 ( Kim Hee-Ok )
한양대학교 의과대학 이비인후-두경부외과학교실
이용섭 ( Lee Yong-Seop )
한양대학교 의과대학 이비인후-두경부외과학교실
이형석 ( Lee Hyung-Seok )
한양대학교 의과대학 이비인후-두경부외과학교실
안유헌 ( Ahn You-Hern )
한양대학교 의과대학 내과학교실
KMID : 0356820060220020117
Abstract
Background & Objectives : Thyroid carcinoma is the sixth commonest cancer in Korea and the papillary carcinoma is the most common type(88%) of the malignant thyroid tumors. Bulky DNA adducts formed by the carcinogens are repaired by DNA repair process, but failure to repair this DNA damage can cause mutations in oncogenes and tumor suppressor genes resulting in tumor formation. The xeroderma pigmentosum group C(XPC) gene is essential for this repair procedure and the XPC-PolyAT(PAT) polymorphisms may alter DNA repair capacity(DRC) and genetic susceptibility to cancer.
Subjects & Methods : In a case-control study of 113 Korean patients with pathologically diagnosed thyroid papillary carcinoma and 65 control subjects, we investigated the association between the three XPC-PAT gene polymorphisms and thyroid papillary cancer susceptibility.
Results : The frequency of the variant XPC-PAT allele was lower in the cases(0.349) than in the controls (0.423), but the difference was not significant(p=0.140). Using logistic regression adjusting for age and sex, risk for thyroid papillary cancer was not increased in the XPC-PAT-/+ and XPC-PAT+/+ compared to XPCPAT-/-(adjusted overall odds ratio[95% confidence intervals;95%CI]=0.52[0.26-1.03] and 0.62 [0.22-1.75], respectively; trend test, p=0.167).
Conclusion : There are no relationship between the XPC-PAT polymorphism and the risk of thyroid papillary carcinoma in Korean population. Based on our results, XPC-PAT polymorphism do not modulate genetic susceptibility to thyroid papillary cancer.
키워드
갑상선암종;유전자 다형
Thyroid cancer;Xeroderma pigmentosum group C(XPC);Polymorphisms;XPC-PAT
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