3, 7-Dimethylbenzanthracene의 부신적출 백서 -피부에 대한 조기반응-
The Early Response of Adrenalectomized Albino Rat Skin to 3, 7-Dimethylbenzanthracene
이대영, 김영제,
소속 상세정보
이대영 ( )
가톨릭대학 의학부 병리학교실
김영제 ( )
가톨릭대학 의학부 병리학교실
KMID : 0357919710050010047
Abstract
It is a well known fact that the skin of rats, wit& a few exceptions, refractory to
polycyclic hydrocarbons.
Hwang and Kim (1971) in our laboratory reported that the early skin reactions of
amino rats to dimethylbenzanthracene.
Reports concerning the chemically induced tumors have been made clear that large
number of them by some investigators were shown to be antigenic and it is suggested
that the oncogenesis due to chemical carcinogen may be related to immune mechanism.
On the other hand adrenalectomy causes marked proliferation of lymphoid tissues,
which are main organs concerning to immune mechanism.
Therefore the authors tried to observe the response of adrenalectomized albino rat
skin to 3, 7-dimethylbenzanthracene.
It was confirmed that the skin reactions in the skin of the adrenalectomized rats
painted with 3, 7-dimethylbenzanthracene simultaneously, consisted of a marked atrophy
of hair follicles, whereas those of the rats pre- or post- painted, a marked proliferation
of hair follicles, proliferation and increased rate of mitotic division of epithelial cells of
the hair follicles.
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