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Cantharidin-induced Hepatic Injury-Part ¥° : Reappraisal of Tissue Reaction Based on Hepatic Injury-
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ÀÌÁ¦±¸(ì°ðÎú)/Chae Koo Lee
±è¿ëÀÏ(ÑÑé¸ìé)/ÀÌÁ¤ºó(ì°ïáÞ¯)/Yong Il Kim/Jung Bin Lee
KMID : 0357919760100010047
Abstract
Hepatic toxic injuries were induced in young male rats by subcutaneous injection of
Cantharidin and their histologic characteristics were summarized as follows ;
1) diffuse swelling of hepatocytes, periportal hepatocullular necrosis with smudging
and degranulation of cytoplasms in addition to focal spotty necrosis,
2) portal vein dilatation with swelling of its endothelial cells and leucocytic
margination, accompanied by periportal congestion, portal exudation and hemorrhage.
With the above histologic features, the main toxic mechanisms of Cantharidin to the
liver may be deduced as mixtures of vascular factor and direct toxic effect to the
hepatocytes.
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