Àü½Å Shwartzman ¹ÝÀÀ±âÀü
A Study on the Mechanism of Generalized Shwartzman Reaction
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À̼ö¿µ/Soo Young Lee
±è¿øÀÏ/À强±Ù/±èÁÖ¼º<ÁÖÀÓ±³¼ö:±è¿µÁ¦>/Won Il Kim/Sung Keun Chang/Choo Soung Kim
KMID : 0357919800140020015
Abstract
The anti-rabbit plasma coagulation factor ?I goat immunoglobulin infusion, prevents
the generalized Shwartzman reaction of rabbits elicited by two 24 hours interval intrav-
enous injections of bacterial endotoxin. Measurements of circulating platelets, fibrinogen
and factor ?I activities were done after either the first or second injection of endotoxin
in both antibody-treated and non-treated rabbits. Twenty four hours after the first
injection of endotoxin, a marked increase of platelet was occurred in antibody-treated
rabbits, however an increase in fibrinogen was appeared in non-treated ones and forty
eight hours after the injection an increase in fibrinogen was greater in antibody-treated
group than in non-treated group. Forty eight hours after the first injection of endotoxin,
plasma factor ?I activities were decreased in non-treated rabbits. The occurrence of
bilateral cortical necrosis was confirmed in four out of five rabbits in non-treated group,
whereas no bilateral cortical necrosis was occurred in antibody-treated group.
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