피부를 침법한 악성 조직구증 -호산구증을 동반한1예보고-
A Case of Mailgnant Histiocytosis with Cutaneous Involvement and Eosinophilia
김진, 이삼열, 김기환,
소속 상세정보
김진 ( )
연세대학교 의과대학 병리학교실
이삼열 ( )
연세대학교 의과대학 병리학교실
김기환 ( )
연세대학교 의과대학 병리학교실
KMID : 0357919810150010085
Abstract
Malignant histiocytosis is a fatal disease chatacterized by systemic proliferation of
atypical, neoplastic and erythrophagocytic histiocytes.
A Case of malignant histiocytosis with multiple nodular cutaneous involvement and
eosinoptilia, in a 18 year-old male, was diagnosed on the third skin biopsy and reported.
The first and second biopies shoved polymorphous, cellular infiltrates around the blood
vessel and skin appendages in the lower dermis and diffuse infiltrates in the
subcutaneous tissue. The infiltrates were composed of histiocytes, eosinophils,
Iymphocytes and plasma cells without significant cellular atypism or abnormal mitoses.
The third biopsy, which was performed 6 months later, when he readmitte4 due to
aggrevation of the symptoms, showed monomorphous atypical histiocytic infiltrate with
cellular atypism, abnormal mitoses, and erythrophagocytosis. Eosinophils, Iymphocytes
and plasma cell infiltrates were markedly decreased. Brief review of the literatures with
special reference to the association of cutaneous involvement and eosinophilia was made.
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