Reye증후군에 의한 간세포의 미세형태학적 구조변화 1예
Ultrastrucrural Changes of Hepatocytes in Reye Syndrome -A Case Report-
김원호, 김영환,
소속 상세정보
김원호 ( )
경희대학교 식품공학과
김영환 ( )
경북대학교 의학대학 병리학교실
KMID : 0357919820160040890
Abstract
요약
저자들은 생후 11월개된 여아의 부검에서 비교적 특징적인 Reye증후군을 발견하였기에 간
세포의 광학현미경적, 관찰 및 생화학적 지방질 분석을 시행하여 그결과를 문헌고찰과 함께
보고하는 바이다. 그 결과로 Reye증후군으로 사망한 예에서도 사인은 심한 뇌부종이 원인과
되며 간세포의 변화는 핵 및 소기관 특이 mito-chondria의 광범위한 손상이 인정되지만 이
들 변화는 아직도 가역적인 변화로 생각된다. 특히 간세포 지방분서에 따라 지방공포들의
성분은 triglyceride가 되부분일 것으로 추정된다.
#초록#
Authors investigated hepatocellular changes in a case of autopsy, 11-month-old female
child, dying of Reye syndrome. Light imcroscopically, microvesicular fatty change of the
liver was a characteristic finding. The hepatocytes were packed with small fatty droplets
without nuclear form and demonstrated by using lipid stains on frozen sections. There
was no cholestasis. The portal tracts had mild lymphocytes infiltration.
Electron microscopically, mitochondria showed conspicuous abnormalities with reduction
in number, pleomorphism, swelling and loss of cristae. Vacuolization and increased
electron density of mitoctondrial matrix were observed. RER were decreased in number
and had some vesicular change ana SER were dilated. Glycogen particles were rarely
seen. nucleus showed some irregular border and clumping of chromatin along the
nuclear membrane. Necleoli wert inconspicuous. Fat vacuoles were located in the central
portion of cotoplasm and some were closed to nucleus. The size were 1∼2μm in
diameter, relatively. Large concealed forms were also present, but were no over 5.5 μm
in diameter. All fat vaculoles were rather solid than empty form.
Biochemically, the compositions of lipids in liver cells revealed 79.6% of triglyceride,
3.8% of cholesterol, and 16.6% of phospholipid. Conclusively, changes of hepatocytes
were thought as reversibleeven in this fatal case and components of fat vacuoles might
be triglycerides mostly.
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