Waldenstrom's Macroglobulinemia 1 예
A Case of Waldenstrom's Macroglobulinemia
소속 상세정보
최성만/Sung Man Choi
김재식/김중명/배한익/김용진/이인걸/이규보/김영태/Jay Sik Kim/Jyug Myung Kim/Han Ik Bae/Yong Jin Kim/In Geol Lee/Gyu Bo Lee/Yung Tae Kim
KMID : 0357919830170030344
Abstract
요 약
저자들은 최근 혈청단백의 면역전기영동에서 IgM-入type의 단일클론감마병증의 소견을
보인 Waldenstrom's macroglobulinemia 1예를 경험하였기에 문헌고찰과 함께 분석 검토하
였다.
#초록#
The Waldenstrom's macroglobulinemia is a slow growing progressive malignant
lymphoproliferative disorder and charaterized by macroglobulin(Ig M) paraprotein 'spike'
on the serum protein electrophoresis associated with bone marrow proliferation of
plasmacytoid lymphocyte. The age at diagnosis of patient is ranging from 4th to 9th
decade and the peak age is 6th to 7th decade. The major criteria for diagnosis are a
monoclonal Ig M serum protein abnormality present in concentrations greater than 1 g/dl
and clinical manifestations included weight loss, bleeding tendency, presence of abnormal
masses ,lymphadenopathy ,hepatosplenomegaly, central and peripheral neuropathy and
hyperviscosity syndrome may develop as a complication of macroglobulinemia. We
experienced one case of Waldenstrom's macroglobulinemia, 68-year-old woman, who
visited our hospital due to slow growing multiple cervical masses. On physical
examination, painless cervical, axillary and inguinal lymphadenopathy, and hepatomegaly
were noted. The hematological study showed moderate degree of normocytic
normochromic anemia. The serum protein elect trophoresis showed typical monoclonal
gammopathy. The serum protein immunoelectrophoresis revealed Ig M-lambda type
M-protein. Concentration of Is M was 3.04 g/dl. Bone marrow aspiration findings were
nonspecific except slightly increase of plasma cells. The findings of bone marrow and
lymph node biopsies showed no evidence of malignancy as lymphoma or leukemia. The
peroxidase antiperoxidase (PAP) and methyl green pyronine stains of bone marrow and
lymph node also showed non-specific findings. The B-lymphocyte count of the
peripheral blood by immunoflurorescent method revealed markedly increased subsets
along with the increased total B-cell counts.
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