Streptozotocin투여가 백서 췌 분비선의 미세구조에 미치는 영향
Ultrastructural Study on Streptozotocin - induced Pancreaitc Acinar Injury in Rats
신형식, 김선호, 김지은,
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신형식 ( )
서울대학교 의과대학 병리학교실
김선호 ( )
서울대학교 의과대학 병리학교실
김지은 ( )
서울대학교 의과대학 병리학교실
KMID : 0357919840180010016
Abstract
Experimental diabetes was produced in Sprague-Dawley rats by single dose of
intraperitoneal injection of streptosotocin, 50㎎/㎏ and sacrificed on the 15 th, 45 th, and
90 th day. Blood glucose levels were 400 ㎎/dl in all groups(normal control : 120 ㎎/dl)
and serum amylase level of a group after 45 days was 621.1 IU of average, whereas
750.5 IU in normal. control group.
The cytoplasms of pancreatic acinar cells were closely packed with minute hydropic
vacuoles and numerous fat globules, measuring 0.5∼1.0μ in diameter. Electron
microscopic findings represented mitochondrial swelling with loss of cristae and
indistinct outlines. Populations of free ribosome were increased, but the gymogen
granules were reduced than those o( control group. The above findings support that
streptogotocin induces acinar cell injure in part through the direct chemical toxicity on
mitochondria.
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