CA電氣泳動法을 利用한 HDL-C 値 및 Total Cholesterol,/ HDL-C, LDL-C/HDL-C値 測定
HDL-C, Total Cholesterol/HDL-C, and LDL-C/HDL C determination by Cellulose Acetate electrophoresis
소속 상세정보
서상철(徐相喆)/Sang Cheol Suh
김재식(金在植)/김중명(金重明)/Jay Sik Kim/Jyung Myung Kim
KMID : 0357919840180030249
Abstract
要 約
冠狀動脈疾患과 關聯이 깊은 HDL-cholesterol은 主로 沈澱法으로 測定하였으나 著者는 電
氣泳動法을 利用하여 各疾患群에 대해 測定하였고 Total cholesterol은 日本 日水製藥株式會
社의 V-Cholestase 卽 酵素法을 利用하여 測定한 後 Total cholesterol과 HDL-cholesterol
의 比, LDL과 HDL-cholesterol의 比를 求하여 各疾患群과 正常對照群과 比較하여 다음과
같이 要約할 수 있었다.
HDL cholesterol의 CA電氣泳動像은 lipornitein의 α-lipoprotein과 一致하였으며 正常成人
男子 64名에서는 54.6±11.0㎎/dl, 女子에서는 18名으로 71.7±13.0㎎/dl이었고 心筋硬塞에서
는 男子가 40.7±13.4㎎/dl, 女子가 38.7±13.1㎎/dl, 다른 心疾患에서는 男子가 43.1±
21.2mg/dl, 女子는 51.0±21.8㎎/dl로 亦是 10㎎/dl 以上 낮은 値를 보여주었고 高血壓에서
男子는 45.2±16.5㎎/dl, 女子가 61.6±8.7㎎/41, 糖尿病患者는 男子가 53.7±25.3㎎/dl, 女子가
55.8±11.8㎎/dl로 男女 性別差는 別로 없었다.
그리고 Total cholesterol/HDL cholesterol, LDL-C/HDL-C의 比는 正常男子가 3.62±0.66,
2.37±0.61, 女子는 2.61±0.40, 1.37±0.32였고 心筋硬塞患者는 男子가 5.31±2.86, 3.81±2.84,
女子는 5.55±1.47, 3.84±1.33으로 統計學的으로 有意性이 있었으며 其他心疾患에서도 男子
가 5.13±1.52, 3.63±1.83으로 어느 程度 有意性이 있었고 糖尿病에서는 女子만 T-C/HDL이
5.07±2.64로 어느程度 有意性이 있었다. 그 外의 境遇는 有意性이 없었으며 特히
LDL-C/HDL-C 値도 어느程度 一致하였다.
#초록#
Previously we mainly used the precipitation method for measuring HDL cholesterol
which was closely related to coronary heart disease.
Now the author performed HDL-cholesterol determination against normal healthy adults,
diabetics, patients of heart disease with or without myocardial infarction, and
hypertension by CA electrophoresis and total cholesterol with V-cholestase(Nissui). After
that, we measured the ratio of total cholesterol/HDL-C and LDL-C/HDL-C in each
group, and then we compared with normal control.
The electrophoretic pattern of HDL cholesterol was corresponding to alpha-lipoprotein.
The HDL cholesterol levels of normal male and female were 54.6±11.0 ㎎/dl and 71.7±
13.0㎎/d1. The levels in myocardial infarction were 40.7±13.4 ㎎/dl in male and 39.7±
13.1 ㎎/dl in female. Those of heart disease without myocardial infarction were 43.1±
21.1 ㎎/dl in male and 51.0±21.8 ㎎/dl in female. The average HDL-C levels of these
disease groups were lower than the normal control about 10 ㎎/dl this data was
statistically significant. In hypertensive disease group, the love is were 45.2±16.5 ㎎/dl
in male, 61.6±9.7 ㎎/dl in female and those of diabetics were 53.7±25.3 ㎎/dl in male,
55.8±11.8 ㎎/dl in female. There was little sexual difference in diabetics.
In the ratio of total cholesterol/HDL-C and LDL-C/HDL-C, normal male was 3.62±
0.66, 2.37±0.61 and normal female 2.61±0.40, 1.37±0.32. Of the myocardial infarction,
male 5.31±2.96, 3.81±2.84, female 5.55±1.47, 3.94±1.33. There was statistically
important difference between normal and myocardial infarction.
Of the other cardiovaccular disease, male was 5. 13±1.52, 3.63±1.83 and in female
diabetics, total cholesterol/HDL-C was 5.07±2.64. Of the cases, a little importance in
comparison with normal.
The remainings had no statistically importance.
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