대장 흑색소증의 전자현미경적 관찰
Ultrastructural Observation on Melanosis Coli
이혜경, 김용일, 임소덕, 백남종,
소속 상세정보
이혜경 ( )
서울대학교 의과대학 병리학교실
김용일 ( )
서울대학교 의과대학 병리학교실
임소덕 ( )
서울대학교 의과대학 병리학교실
백남종 ( )
서울대학교 의과대학 외과학교실
KMID : 0357919840180040425
Abstract
Histochemical and ultrastructural observations were carried out on pigments in
melanosis coli from a 71 years old male who has taken laxatives (laxenta and dulcolax)
for 3 years and received a left hemicolectomy on adenocarcinoma of the descending
colon. The pigments were confined within the lamina propria of entire non-neoplastic
colonic mucosa and showed histochemical reactions similar predominantly to lipofuscin
but with partial overlapping with those in melanin pigments. Ultrastructurally, the
denatured mitochondria and endoplasmic reticulum were demonstrated within the
pigmented granules and in the macrophages to suggest that pigments are of lipofuscin
derivatives which originate from the denatured lipoprotein membranes of cytoplasmic
organelles of injured colonic epithelial cells.
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