À§¾ÏÁ¶Á÷¿¡ ÀÖ¾î¼ÀÇ ¥â-glucuronidase¿Í Lactic Dehydrogenase È°¼ºµµ¿¡ °üÇÑ ¿¬±¸
A Study of ¥â-glucuronidase and Lactic Dehydrogenace Activities in the Neoplastic Tissue of Stomach Carcinoma
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KMID : 0357919850190020141
Abstract
¿ä ¾à
ÀúÀÚ´Â ÀýÁ¦µÈ À§µéÁß ¾ÏÀÌ ¹ß»ýÇÑ À§ 27¿¹¸¦ ´ë»óÀ¸·Î ¾ÏÁ¶Á÷³»ÀÇ ¥â-glucuronidase¿Í
LDHÈ°¼ºµµ¸¦ »ýÈÇÐÀû ¹æ¹ýÀ¸·Î ÃøÁ¤ÇÏ¿´´Ù. À§¾Ï Á¶Á÷³» ¾ç È¿¼ÒÀÇ È°¼ºµµ´Â ¾ÏÀÌ Ä§¹üÇÏ
Áö ¾Æ´ÏÇÑ ±×¸®°í À弱ȻýÀÌ »ý°Ü ÀÖ´Â À§µ¿ºÎÀÇ Á¡¸·°ú ¾ÏÀÌ Ä§¹üÇÏÁö ¾Æ´ÏÇÑ À§Ã¼ºÎÀÇ
Á¡¸·¿¡¼ ÃøÁ¤¶õ À̵é È¿¼ÒÀÇ È°¼ºµµ¿Í ºñ±³ÇÏ¿´À» »Ó ¾Æ´Ï¶ó, °üÂû´ë»óÀ» ¾ÏÀÇ ºÐÈÁ¤µµº°
¹× ¿µ¿ªÀÓ Æļ±¿¡ÀÇ ÀüÀÌ À¯¹«º°·Î ³ª´©¾î ºñ±³ÇÏ¿´´Ù. ÀÌ·¸°ÔÇÏ¿© ¾òÀº ¼ºÀûÀ» ´ÙÀ½°ú °°
ÀÌ ¿ä¾àÇÏ´Â ¹ÙÀÌ´Ù.
1) À§¾ÏÁ¶Á÷³» ¥â-glucuronidaseÂû¼ºµµ´Â ÀÎÁ¢ÇÑ À§Á¡¸· Á¶Á÷³»ÀÇ ÀÌ È¿¼ÒÈ°¼ºµµº¸´Ù ¶Ñ
·ÇÀÌ ³ô¾Ò°í, À弱ȻýÀÌ »ý±ä À§µ¿ºÎÁ¡¸·³» ÀÌ È¿¼Ò È°¼ºµµ´Â À§Ã¼ºÎÁ¡¸·¿¡¼ º¸´Ù ¶Ñ·ÇÀÌ
³ô¾Ò´Ù.
2) À§¾ÏÁ¶Á÷ÀÇ lactic dehydrogenaseÈ°¼ºµµ´Â À弱ȻýÀÌ »ý±ä À§µ¿ºÎÁ¡¸·ÀÇ È¿¼ÒÈ°¼ºµµ¿Í
ºñ½ÁÇÏ¿´°í, À§Ã¤ºÎ Á¡¸·º¸´Ù´Â ¶Ñ·ÇÀÌ ³ô¾Ò´Ù.
3) ¥â-gtucuronidase¿Í lactic dehydrogenaseÈ°¼ºµµ±Ù ´Ù°°ÀÌ ¹ÌºÐȾϿ¡¼ º¸´Ù ºÐȾÏÁ¶
Á÷¿¡¼ ³ôÀº °æÇâÀ» º¸¿´À¸³ª, Åë°èÀûÀ¸·Î À¯ÀÇÇÑ Â÷´Â ¾Æ´Ï¿´´Ù.
4) ¾ÏÁ¶Á÷³»ÀÇ ¥â-glucuronidase¿Í lactic dehydrogenaseÈ°¼ºµµ´Â ÀÎÁ¢ À§Á¡¸·¿¡½Ã º¸´Ù
»ó½ÂµÇ¾î ÀÖ¾úÀ¸³ª, ¾çÀÚ»çÀÌ¿¡ »ó°ü°ü°è´Â ÀÎÁ¤µÇÁö ¾Æ´ÏÇÏ¿´´Ù.
#ÃÊ·Ï#
To observe whether the measurement of enzyme activity has any critical role in
assesment of diagnostic value, ¥â-glucuronidase and lactic dehydrogenase activities in
neoplastic tissue of stomach were compared with those in the stomach at the stomach
mucosa at the antrum and body which was uninvolved by tumor. And then activities of
those enzymes were also compared with differentiated and undifferentiated carcinomas.
The stomach tested were obtained by gastrectomy in Pusan national University Hospital
during the months from March to June in 1983.
The rests were summarized as follows :
1) ¥â-glucuronidase activity in the neoplastic tissue of stomach was higher than that
in the antral and body mucosa, and this enzyme activity in the antral mucosa with
intestinal metaplasia was higher than that in the body mucosa of stomach.
2) Lactic dehydrogenase activity in the neoplastic tissue of stomach was similar to
that in the antral mucosa with intestinal metaplasia, and was higher than that in the
body mucosa of stomach.
3) Activities of both enzymes in the neoplastic tissue of differentiated carcinoma were
slightly higher than that of undifferentiated one, but did not found statistically
significant difference.
4) In the neoplastic tissue of the stomach there was no significant correlation between
¥â-glucuronidase and latin dehydrogenase activities. Above results support that the
measurement of gastric juice enzymes is useful in the diagnosis of stomach carcinoma
and may be of value in the identification of high-risk groups.
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