Serotonin, Somatostatin 및 Gastrin양성 위 선암 세포에 대한 면역조직화학적 연구
Immunohistochemical Studies on the Serotonin, Somatostatin and Gastrin-Positive Cells in the Gastric Adenocarcinoma
최찬, 김대현,
소속 상세정보
최찬 ( )
이화여자대학교 의과대학 의과학연구소
김대현 ( )
전남대학교 의과대학 병리학교실
KMID : 0357919850190040391
Abstract
In order to study the histogenesis of gastric carcionma, and to find the correlationship
between the gastric carcinoma and endocrine tumor of digestive tract, we performed
immunoperoxidase staining for serotonin, somatostatin and gastrin respectively in the 34
cases of surgically resected gastric carcinoma The results were as follows ;
1) Endocrine fells were found in 26.5 % (9/34) of the gastric adenocarcinoma, but in
58.6% (17/29) in the normal gastric mucosa near the cancer area. The occurence of
endocrine cells was less frequent in cancer than in the normal gastric mucosa.
2) Among the If cases of intestinal type adenocarcinoma, serotonin-positive cells were
found in 2 cases, somatostatin-positive cells in 1 case and gastrin-positive cells in 1
case. Among 16 case of diffuse type ade-nocarcinoma, gastrin-positive cells were found
in 2 cases, and somatostatin-positive cells were found in 2 cases.
3) We concluded that, the endocrine cells are more frequently observed in the well
differentiated gastric carcinoma than poorly differentiated carcinoma tissue.
In summary, gastric carcinomas are supposed to arise from the totipotent stem cells
of endoderm origin, and they have multidirectional property of differentiation into both
endocrine and nonendocrine cells. Most of them differentiate into nonendocrine cells and
only a few of them differentiate into endocrine cells.
키워드
원문 및 링크아웃 정보
등재저널 정보