한국인의 만성 간염과 간 경변증에서의 항 평활근 항체 및 항 핵 항체의 출현빈도
Study on the Anti-Smooth Muscle Antibody and Anti-Nuclear Antibody of Chronic Active Hepatitis, Chronic Persistant Heratitis and Liver Cirrhosis in Korea
이갑노, 백승룡, 이상국,
소속 상세정보
이갑노 ( )
고려대학교 임상병리학교실
백승룡 ( )
고려대학교 임상병리학교실
이상국 ( )
서울대학교 병리학교실
KMID : 0357919860200020147
Abstract
In Korea chronic liver diseases are the important medical issues because of their high
incidence, poor prognosis and no available therapeutic resume. It is believed that the
etiologic agent of most of chronic liver diseases in Korea is hepatitis B virus.
To find out the incidence of positivity and to understand the autoantibodies in some of
the chronic liver diseases in Korea, anti-smooth muscle antibody and anti-nuclear
antibody tests were performed on 43 patient serum with chronic active hepatitis, 13
patient serum with chronic persistant hepatitis and 20 patient serum with liver cirrhosis,
who diagnosed by liver biopsies.
The results of the study are summarized as follows:
1) The positivity of anti-smooth muscle antibody in chronic active hepatitis was 93.0%,
that in chronic persistant hepatitis 60.0% and that in liver cirrhosis 80.0%.
2) The positivity of anti·nuclear antibody in chronic active hepatitis was 18.6%, that
in chronic persistent hepatitis 15.4%, that in liver cirrhosis 5.0%.
3) The test efficiency of anti-smooth muscle antibody to differentiate chronic active
hepatitis from chronic persistant hepatitis and liver cirrhosis was 48.7%
The above results suggest that the antismooth muscle antibody may be related to the
"necrosis of liver cells", and further studies are needed to fine out any relationship
between the autoantibody and the disturbance of immune regulato교 function if there is,
as this study suggested.
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