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Abstract

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The occurrence of squamous metaplasia(morule) in colorectal mucosa and
adenocarcinoma, althrough rare, has been well documented. In contrast, very little
mention has been given to mature squamous cells seen in colorectal polyps or
adenomas.
A 42-year-old woman presented with a 2-month history of diarrhea and melena.
Proctosigmoidoscopy revealed a 4 cm-sifted Polypoid tumor 20cm above the anal verge.
Colonoscopic biopsy showed tubular adenoma, and a segmental resection of sigmoid
colon was done. Microscopically, the tumor was a classical tubular adenoma containing
multiple solid nests of squamous cells scattered only in the neoplasm; the squamous
nests were generally small, and some showed direct continuity with adenomatous glands.
The squamous cells were keratinizing and had regular nuclei with no mitotic activity.
The importance of this phenomenon lies in its pathologic recognition, and the findings
suggest that awareness of this rare occurrence in colorectal Polyps should avert such
overdiagnosis, and consequently prevents unnecessary radical surgery. (Korean J Pathol
1993: 27: 663-665)

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Squamous metaplasia; Tubular adenoma; Colon;

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KCI
KoreaMed
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