기질에 유파골세포형 다핵거대세포를 동반한 유방의 침윤성 관암종 -1예 보고-
Infiltrating Ductal Carcinoma of the Breast with Stromal Osteoclast-Like Multinucleated Giant Cell -A case report-
백소야, 이상엽, 이봉기, 신동환,
소속 상세정보
백소야 ( )
연세대학교 의과대학 병리학교실
이상엽 ( )
연세대학교 의과대학 병리학교실
이봉기 ( )
연세대학교 의과대학 병리학교실
신동환 ( )
연세대학교 의과대학 병리학교실
KMID : 0357919960300010061
Abstract
유방암종에서 기질에 유파골세포형 다핵거대세포를 동반하는 경우는 매우 드물다. 1910년
처음으로 기술된 이후로 현재까지 세계적으로 약 40예가 보고되어 있으며 국내 문헌보고는
없다 저자들은 최근 기질에 유파골세포형 다핵거대세포를 동반한 유방의 침윤성 관암종 1예
를 경험하였기에 면역조직 화학적 염색 및 전자현미경 검사를 통해 이 세포의 기원과 임상
적 의의를 밝히고자 하였다.
#초록#
Malignant tumors of the breast which contain stromal osteoclast-like, multinucleated
giant cells are a rare entity of yet unknown clinical significance. These benign
multinucleated giant cells are known to occur mostly in areas of prominent angiogenesis
and ill close association with tumor cells. Supplementary immunohistochemical and
electronmicroscopic examinations indicate that the multinucleated giant cells are of
histiocytic origin.
We report on a case of infiltrating ductal carcinoma with stromal osteoclast-like
multinucleated giant cells occurring in the right breast of a 37 year-old woman. Grossly,
the tumor was characterized by a well-circumscribed dark brown, solid firm mass.
Microscopically, multinucleated giant cells were found in the stroma intermingled with
malignant tumor cells. The stroma showed only a small amount of mononuclear cell
infiltration and a moderate degree of vascular proliferation. Immunohistochemical stains
revealed the tumor cells to be positive for carcinoembryonic antigen, epithelial membrane
antigen and cytokeratin while the multinucleated giant cells were positive for vimentin,
CD68 and negative for all other stains tested. Ultrastructurally the multinucleated giant
cells differed from tumor cells by having abundant cytoplasmic organelles such as rough
endoplasmic reticulum, lysosomes, ribosomes, and vesicles but lacking desmosomes or
other types of intercellular junctions. Other characteristic features of multinucleated giant
cells included, indented nuclei and prominent cytoplasmic process. (Korean J Pathol 1996;
30: 61∼64)
키워드
Osteoclast-like multinucleated giant cell; Breast carcinoma;
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