유방 엽상종양의 예후추정 인자로서의 DNA 배수성 분석
DNA Ploidy Analysis as a Prognostic Indicator in Phyllodes Tumor of the Breast
김희정, 한재호, 정우희, 이희대,
소속 상세정보
김희정 ( Kim Hee-Jung )
연세대학교 의과대학 병리학교실
한재호 ( Han Jae-Ho )
연세대학교 의과대학 병리학교실
정우희 ( Jung Woo-Hee )
연세대학교 의과대학 병리학교실
이희대 ( Lee Hy-De )
연세대학교 의과대학 외과학교실
KMID : 0357919990330070507
Abstract
DNA ploidy analysis using flow cytometry was performed on sixty six cases of phyllodes tumor of the breast including benign, low grade and high grade malignant phyllodes tumor. The rate of aneuploidy was 41.2% in high grade malignant phyllodes tumor and 4.8% in benign phyllodes tumor. No aneuploidy was noted in low grade malignant phyllodes tumor. The recurrence rate according to DNA ploidy pattern revealed 16.7% of aneuploidy and 7.7% of diploidy. In the aneuploid cases, the DNA index of high grade malignant phyllodes tumor was higher than benign phyllodes tumor. Morever, in diploid cases, %SG2M were significantly higher in high grade malignant phyllodes tumor. Therefore, we conclude that DNA ploidy analysis as well as histologic characteristics such as cellularity, pleomorphism of stromal cells and mitoses is useful parameters in the diagnosis, recurrence and prognostic predictors of phyllodes tumor.
키워드
Breast;Neoplasm;Phyllodes tumor;DNA ploidy;Flow cytometry;Prognosis
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