16번 삼염색체증 마우스에서 관찰된 이상 뇌발달과 세포자멸사
Abnormal Development and Apoptosis Observed in Brains of the Trisomy 16 Mouse
조은윤, 서연림, 지제근,
소속 상세정보
조은윤 ( Cho Eun-Youn )
성균관대학교 의과대학 삼성서울병원 진단병리과
서연림 ( Suh Yeon-Lim )
성균관대학교 의과대학 삼성서울병원 진단병리과
지제근 ( Chi Je-Geun )
서울대학교 의과대학 병리학교실
KMID : 0357919990330080570
Abstract
We have studied morphologic characteristics and apoptosis on the fetal brain of the trisomy 16 mouse, a model for human trisomy 21 syndrome. This study was based on serial sections of the whole brain from a sample of sixteen trisomy 16 mice and forty-six age-matched control littermates from embryonic day (ED) 12 to ED 18. Trisomy 16 brains showed a reduction of telencephalic size and abnormal cortical development. At ED 13 trisomy 16 and control brains appeared similar. By ED 14 difference in the cortical thickness and telencephalic growth became evident, and by ED 16 a marked size difference had developed between the trisomy 16 and control brains. By ED 18, however, the thickness of the trisomy 16 cortex had increased considerably and was not significantly different with respect to the thickness and cross-sectional areas of the pallium and its constituent cortical layers. The cell density of the trisomy 16 cortex had persistently decreased before ED 17, when the cell density of control and trisomy 16 corteces was similar within each layer. At ED 18 cell density of trisomy 16 cortex in each layer increased. There was inverse relationship between a number of TUNEL positive apoptotic cells and cell density in the trisomy 16 brains. Our results suggest that developmental abnormalities of the trisomy 16 brain indicated developmental delay of the telencephalon growth, which may be caused by apoptosis rather than by a proliferation defect.
키워드
Trisomy 16 mouse;Down syndrome;Brain development;Apoptosis
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