난소암종에서 종양 신생혈관형성과 병기와의 관계
Tumor Angiogenesis and Stage in Ovarian Carcinoma
장은숙, 주현창, 이태성,
소속 상세정보
장은숙 ( Chang Eun-Sook )
계명대학교 의과대학 병리학교실
주현창 ( Joo Hyun-Chang )
계명대학교 의과대학 병리학교실
이태성 ( Lee Tae-Sung )
계명대학교 의과대학 산부인과학교실
KMID : 0357919990330080596
Abstract
Tumor angiogenesis has been found to have prognostic significance in many tumor types for predicting an increased risk of metastasis. We assessed tumor vascularity in 28 cases of borderline malignancy and 71 cases of carcinoma of the ovary which had been resected and diagnosed, using the highly specific endothelial cell marker CD34. The numbers of microvessels were counted in 200 magnification in three highly vascularised areas. The numbers of microvessels in carcinomas were higher than that in the borderline malignancy of serous and mucinous tumors. The number of microvessels of mucinous carcinomas was significantly higher than that of serous carcinomas. There were neither significant differences in the number of microvessels according to histological tumor types (p=0.075) nor significant differences in the number of microvessels according to FIGO stages (p=0.072). But in serous carcinomas, the number of microvessels was higher in the FIGO III-IV stage than in the FIGO I-II stage (p=0.017). This study showed higher neovascularization in malignant tumor than borderline malignancy, and in the advanced stage (FIGO III-IV) than less advanced stage (FIGO I-II) of serous carcinomas.
키워드
Angiogenesis;Ovarian carcinoma;Microvessel;FIGO stage
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