백서에서의 망간 과다폭로에 관한 실험적 연구 - 대뇌 망간의 분포와 신경병리 및 면역조직화학적 연구를 중심으로 -
Manganese Intoxication in the Rat - A neuropathologic study and distribution of manganese in rat brain -
장석용, 김정란, 이종임, 김동훈, 김기권, 김지용, 정해관, 임현술,
소속 상세정보
장석용 ( Jang Suk-Yong )
동국대학교 의과대학 병리학교실
김정란 ( Kim Jung-Ran )
동국대학교 의과대학 병리학교실
이종임 ( Lee Jong-Im )
동국대학교 의과대학 병리학교실
김동훈 ( Kim Dong-Hoon )
동국대학교 의과대학 병리학교실
김기권 ( Kim Ki-Kwon )
동국대학교 의과대학 병리학교실
김지용 ( Kim Ji-Yong )
동국대학교 의과대학 예방의학교실
정해관 ( Cheong Hae-Kwan )
동국대학교 의과대학 예방의학교실
임현술 ( Lim Hyun-Sul )
동국대학교 의과대학 예방의학교실
KMID : 0357919990330090662
Abstract
We investigated a topographical distribution of managanese, and immunohistochemical density of tyrosine hydroxylase (TH), and histopathologic findings in globus pallidus and substantia nigra according to manganese dose and time course in the brain of rats which received MnCl2 intravenously. Topographical distribution of manganese was also investigated after injection of FeCl2. The manganese concentrations of brain in control and experimental group were highest in pituitary gland and thalamus, and lowest in the cerebral cortex. The manganese concentration of blood was increased proportionally to the dose administered, and the biological half-life of blood manganese was between 21 and 42 days. The manganese concentrations of brain were increased proportionally to the dose, and increase rate was highest in olfactory bulb, and the biological half-lives of brain manganese ranged from 42 days to 90 or more days; the longest were observed in pituitary gland, medulla oblongata and cerebral cortex. In case of administration of FeCl2, the manganese concentrations of brain were higher than that of control group in dose of 2.5 mg/kg, and decreased proportionally to the administered dose, resulting in lower level compared with control group in high dose of FeCl2 administered. Significantly decreased number of nerve cell and increased gliosis in globus pallidus were observed in experimental group, which were closely correlated with the duration after manganese injection, but no significant change of number of nerve cell expressing TH and gliosis were observed in substantia nigra. Density of immunohistochemical reaction for TH in globus pallidus made little difference between control and experimental group. These results suggest that pathology of manganese intoxication is caused by the loss of nerve cells in globus pallidus, and closely correlated with the duration after manganese exposure.
키워드
Manganese;Brain;Distribution;Globus pallidus
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