위선암종에서 Sialosyl Tn 점액항원의 발현과 예후인자와의 상관관계
Expression of Sialosyl Tn Mucin Antigen in Gastric Adenocarcinoma and Its Relationship with Prognostic Factors
장선희, 김호정, 성순희, 구혜수, 한운섭,
소속 상세정보
장선희 ( Chang Sun-Hee )
이화여자대학교 의과대학 병리학교실
김호정 ( Kim Ho-Jung )
이화여자대학교 의과대학 병리학교실
성순희 ( Sung Sun-Hee )
이화여자대학교 의과대학 병리학교실
구혜수 ( Koo Hea-Soo )
이화여자대학교 의과대학 병리학교실
한운섭 ( Han Woon-Sub )
이화여자대학교 의과대학 병리학교실
KMID : 0357919990330090695
Abstract
Sialosyl Tn mucin antigen (STn) is a carbohydrate antigen of tumor associated mucin formed by the premature 2∼6 sialation of N-acetylgalactosamine. STn has been expressed in several tumor types and showed prognostic significance in colonic carcinoma. The authors evaluated the expression of STn immunohistochemically and correlated its expression with clinicopathologic variables in 100 gastric cancers. In early gastric cancer, STn was expressed in 24 cases out of 50 cases (48%). In advanced gastric cancer, STn was expressed in 48 of 50 (96%). The difference in STn expression between advanced gastric cancer and early gastric cancer was statistically significant. The difference in STn expression between tumors with lymph node metastasis and those without lymph node metastasis, between tubular adenocarcinoma and signet ring cell carcinoma, and between intestinal type and diffuse type adenocarcinoma was statistically insignificant in early or advanced gastric adenocarcinoma. These results suggest that the STn expression plays a role in the tumor progression in both early and advanced gastric adenocarcinomas.
키워드
Sialosyl Tn;Stomach;Adenocarcinoma
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